Genomic Feature
tp85c
- ID
- ZDB-ALT-980203-358
- Name
- tp85c
- Synonyms
-
- P85C (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
-
European Zebrafish Resource Center (EZRC)
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Zebrafish International Resource Center (ZIRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 9: 41107083 (GRCz11) (1) Details
- Nucleotide change
- G/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>T (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Leu>Phe at position 167 (1)
- Flanking Sequence
-
GTTTATTCAGGCTGGCCTCTACTTTGGCTTATATCATTGAAACACGACACCAAAAACAAAAATGGTGACATGCTGTCAGCAGAATCCACAGATGCCACATGAGCAGAAAGCATGTTGCTTTCTCAATATTAGACGTTTGACGGCTGGAAAGCTTTAGCTTAATACAATAACATACAAAACCTGTTTGTCCTGGTGTCGCTGAGGTCATGAACCCTTACAGCAGACAAAATGAGGCTCGCTGAACTGTTATTTGTTCTGAACCATTCCTGAATATTAAGTCTAAGCTTTTTTTGTAATGCCAGTGGGCTAACAAATAATAGTATTGGCTGCTATTTTTGGACACTGTGACATTTTTAACAGCATTCCTTGTCATTGCAGACAACATGCTACATAATGGTCATCTCCATTGCTAATATCGCTAACCTGGCCAGCACAGCTATGTCCATCACCATCCAAAGAGACTGGGTTGTGGTTGTGGCTGGAGATGATCGGAGCAAATT
G/T GCAGGTAAGGAGTTTCAGCTTTTTGAGATTCCATTACAGCGGCTACAAAAAGCATTTTGACAGTGCAAGACTGTATAACAATTATAATTACACCATTTATAGTTCATTGCACTGTAAACAGGGTAATGTAAGCAGATTCAACTAGGTCATAGTTCACCATATTAACTAGAATTTGGTTTGACAATAAAAAAAGTGTTTAAATCATTCTTTATTTGACCAATATAACTAAAATGTTGATTGTTTTGTATATAAATAACATTTTATTTAATGTACTTTAACTTTAAATTCGTTTTTTGGCCATTGTACATTTTTTACTACTGTAAAAGTCATTCCACTTAGTGGAAAGAAGCTCATAAAACACATTATAACTCTTTCTCCATCAGTCATCTTATCTTTATAGAGTGCTTGCATCAGCTGTCCTTTTGTATGGCTTTTTTTAAACCCGCCAATGTACCAAGTGAACCCAGTAACCTCCAGGAAATCCGTGAAAGCAAGCAAAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| slc40a1tp85c/tp85c | Homozygous | Unknown | 3 figures  from 3 publications | 2 figures from Fraenkel et al., 2005 | |
| slc40a1tp85c/tp85c | Homozygous | ♀+/- ♂+/- | 3 figures from Bo et al., 2016 | 2 figures from Bo et al., 2016 | |
| slc40a1tp85c/+ (AB) | Heterozygous | Unknown |
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Supplemental Information
- Genotyping protocol
- None
- Bo, L., Liu, Z., Zhong, Y., Huang, J., Chen, B., Wang, H., Xu, Y. (2016) Iron deficiency anemia's affect on bone formation in zebrafish mutant. Biochemical and Biophysical Research Communications. 475(3):271-6
- Gibert, Y., Lattanzi, V.J., Zhen, A.W., Vedder, L., Brunet, F., Faasse, S.A., Babitt, J.L., Lin, H.Y., Hammerschmidt, M., and Fraenkel, P.G. (2011) BMP Signaling Modulates Hepcidin Expression in Zebrafish Embryos Independent of Hemojuvelin. PLoS One. 6(1):e14553
- Fraenkel, P.G., Traver, D., Donovan, A., Zahrieh, D., and Zon, L.I. (2005) Ferroportin1 is required for normal iron cycling in zebrafish. J. Clin. Invest.. 115(6):1532-1541
- Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., Paw, B.H., Drejer, A., Barut, B., Zapata, A., Law, T.C., Brugnara, C., Lux, S.E., Pinkus, G.S., Pinkus, J.L., Kingsley, P.D., Palis, J., Fleming, M.D., Andrews, N.C., and Zon, L.I. (2000) Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 403(6771):776-781
- Oates, A.C., Brownlie, A., Pratt, S.J., Irvine, D.V., Liao, E.C., Paw, B.H., Dorian, K.J., Johnson, S.L., Postlethwait, J.H., Zon, L.I., and Wilks, A.F. (1999) Gene duplication of zebrafish JAK2 homologs is accompanied by divergent embryonic expresssion patterns: only jak2a is expressed during erythropoiesis. Blood. 94(8):2622-2636
- Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
- Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (Cambridge, England). 123:311-319
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