Genomic Feature
tm98
- ID
- ZDB-ALT-980203-1108
- Name
- tm98
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 15: 20465637 (GRCz11) (1) Details
- Nucleotide change
- T/G
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- None
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CACCATCTTCTGCTTATAGTTTGATTTGTCACTGGAATGTGTGTCTACAGAGGTGGATCTGAGCGCCATATCTTTATTGGACACCTTAAATGGGCCACCAGGAATAAGGAAGGCCTCCTTCTCTCTACCTAAAGTGGAGGTTGGGCTCAAAGAAATGCGATTATTGACAGAATCCAGGTTGTTTCGAACTGTGGTTGAGCTGGCTTTGTGGTTCTGACGCATCTGTCGCAGGACCACAATGGCAGCACAGATCACTAAGGTTAGAGTAATGAGGCCTAGAGTAAATGAGACTATTAAGGCTGCTGGAAGAGCAGGGCTGTTCACAGGCGTGGGCTTCTGTTTGTACTCGCACTGTGTGCCCATGAAGCCTGCCGGGCACTGGCAGACAGGCCCAGAGAAGTGAGTGTAGCAGGTTCCTCCGTTCTGGCAGGGCATGAAACTGCAGGCGTCAGAGCGAACCCTACAGTCCTTGCCTGAGAAACCAAGCGTGCATGTGCAGG
T/G GTACCCGTTGATACCATCCACGCAGGTGCCTGCATTTTGACAGGGGTTGCTTGAGCAGTCGTCAATGTTTGTTTCACAACGTGAGCCTGTGAACCCGGGCCGGCAACGGCACGTCGCTTTGTTGCCCAAATCGAGACACTGGCCACCTTTAAAAAAAATGCAGGGTGTTAACGTAATAAGCCTAAAATTTTGGAAAGTGAAATTGAATAATTAGGACAAAGGAGTACACCAGGGCAAGCAACCCTTGGGAAAGCAATGGTGCATGTTTTAGACTAATAAAGGTCTATTGCTTTATGACAGCTCTATCTCACCATATCAGTGTAAGAGTCTCACTGGCGTCTGTTCTATCATGCATGAGTAGTATGTCACGCACAGTTGACGAATCCCAAAACAAAAAAAGCTGAAGGATCAGCATGTTTCAAGAGGTGTAGATGGCTGGAATGAATTGCATTTAGGACTGAAAATAAGTGCAAAATATTCTCACCGTTAGCACAGGGGTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dlctm98/tm98 | Homozygous | Unknown | 2 figures from 2 publications | 10 figures  from 8 publications | |
| dlctm98/tm98 | Homozygous | ♀+/- ♂+/- | Fig. 4 from Choorapoikayil et al., 2012 | 3 figures from 2 publications | |
| dlctm98/tm98 + MO3-dlc + MO4-dlc | Complex | Fig. 5 from Oates et al., 2005 | |||
| dlctm98/tm98; her1hu2124/hu2124 | Complex | Fig. 4 from Choorapoikayil et al., 2012 | 2 figures from Choorapoikayil et al., 2012 | ||
| dlctm98/tm98 + MO1-her7 + MO2-her7 | Complex | Fig. 5 from Oates et al., 2005 |
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Supplemental Information
- Genotyping protocol
- None
- Lu, Y.F., Liu, D.W., Li, I.C., Lin, J., Wang, C.M., Chu, K.C., Kuo, H.H., Lin, C.Y., Yih, L.H., Jiang, Y.J., Hwang, S.L. (2021) Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos. PLoS Genetics. 17:e1009969
- LLeras Forero, L., Narayanan, R., Huitema, L.F.A., VanBergen, M., Apschner, A., Peterson-Maduro, J., Logister, I., Valentin, G., Morelli, L.G., Oates, A., Schulte-Merker, S. (2018) Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock. eLIFE. 7
- Tavares, B., Jacinto, R., Sampaio, P., Pestana, S., Pinto, A., Vaz, A., Roxo-Rosa, M., Gardner, R., Lopes, T., Schilling, B., Henry, I., Saúde, L., Lopes, S.S. (2017) Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer.. eLIFE. 6
- Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M. (2014) Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Developmental Biology. 391(2):196-206
- Choorapoikayil, S., Willems, B., Ströhle, P., and Gajewski, M. (2012) Analysis of her1 and her7 Mutants Reveals a Spatio Temporal Separation of the Somite Clock Module. PLoS One. 7(6):e39073
- Cutty, S.J., Fior, R., Henriques, P.M., Saude, L., and Wardle, F.C. (2012) Identification and expression analysis of two novel members of the Mesp family in zebrafish. The International journal of developmental biology. 56(4):285-294
- Herrgen, L., Ares, S., Morelli, L.G., Schröter, C., Jülicher, F., and Oates, A.C. (2010) Intercellular Coupling Regulates the Period of the Segmentation Clock. Current biology : CB. 20(14):1244-1253
- Jänicke, M., Carney, T.J., and Hammerschmidt, M. (2007) Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo. Developmental Biology. 307(2):258-271
- Mara, A., Schroeder, J., Chalouni, C., and Holley, S.A. (2007) Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC. Nature cell biology. 9(5):523-530
- Shankaran, S.S., Sieger, D., Schroter, C., Czepe, C., Pauly, M.C., Laplante, M.A., Becker, T.S., Oates, A.C., and Gajewski, M. (2007) Completing the set of h/E(spl) cyclic genes in zebrafish: her12 and her15 reveal novel modes of expression and contribute to the segmentation clock. Developmental Biology. 304(2):615-632
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