Genomic Feature
hzu17
- ID
- ZDB-ALT-221102-6
- Name
- hzu17
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Mugen Liu Lab
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 23: 3408487 - 3408493 (GRCz11) (1) Details
- Nucleotide change
- ACTCCTA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CTGACCCGGGTGGCCGTGCGGGTGGTGATGGTGGTGGTGGCGGTGGTGGAGCTGCTCGGGCGAGGTAGGAGAAGGGCTGTCGGGATCCTGGCTGTGGTGGTGGTGGTGGTGATGGTGGGGGTGGTGGCCGTGAGCGCCGGGGTGACCCGACAGGTCGTCGGGGTGATGGGGGATCGCGCCGTACTGGTGTTGATGGTGATGGTGCTGCGGCTGCTGCTGCTGCTGTTGCTGCGCGTGGCCGTGGTGGTGATGCGCGCCCCTGTATCCATCAAACGCTCCAGCTTGCAGCTGCTGCTGCACGTGAGGGGGCGGCGGGTGCCCGTGGGCCGTGGCACCGATCAGAGCCTCCACCGCGTCTTCGGGCGTGAGGCTTAACGTCTGCGGGTCGATCTGCTGCGGGTACGCGCCGCTGGGCATCCAGTACAGCTCCTCCAGGTGGTTCTTCTGTTCTGTGGGGCTGAAGCTCGGGGAGGACGGCACGGAGCTGCACGGGGTGCTGA
ACTCCTA/- GGAGGACACGGAGCCCTGCGGCTGGAGGCGGTTGCACTGCCGTATATTGGCGCGGTCGTGCGCCGCCATGGCCTCTTTCTTTACCTCGAATTTCATTAAATCAAAGTCATTGACATATTCCAACGCCAGCGGGCTGGTGGGCAGCTCGGGCCCCATGGCGAGATCGGCGCTCATCGTGCCCCTGTTCTTCAGCAAAGTGTTGGGAAAACCAGACTTTGGCGTTTTTTCTCCCCTCTCTTTGCGCATGCAATGTTCTTGATGGGTCTCCGACCGCGGCGCGCTCGAGCGCTGGAGCATACAGTGTCACTCGATTGTGCTCGAACAACAGAAAGCCAAAAACTTTCAGGACTAATGCACCGCGAAAGACATCTGCCTCATATGGACGCGCAGAGCTCGACAGCTGCAGTCTTTGGAGTCTACTCGCGGCGCTGGAGAAAGTCAAGTCTCTCGCGCGCTCAATGTCCCGTCGCAGCACTTCAACTCAAAACATAAATAAAAGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mafbahzu17/hzu17 | Homozygous | Unknown | 7 figures  from Chen et al., 2021 | 4 figures from Chen et al., 2021 | |
| mafbahzu17/hzu17; nrlhzu16/hzu16; kj2Tg | Complex | 2 figures from Liu et al., 2022 | Fig 8 from Liu et al., 2022 | ||
| mafbahzu17/+; nrlhzu16/hzu16; kj2Tg | Complex | Fig 8 from Liu et al., 2022 | Fig 8 from Liu et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Liu, F., Qin, Y., Huang, Y., Gao, P., Li, J., Yu, S., Jia, D., Chen, X., Lv, Y., Tu, J., Sun, K., Han, Y., Reilly, J., Shu, X., Lu, Q., Tang, Z., Xu, C., Luo, D., Liu, M. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLoS Genetics. 18:e1009841
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
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