Genomic Feature
zf3494
- ID
- ZDB-ALT-220930-10
- Name
- zf3494
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Development and functional regulation of BBB
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 10: 43994804 - 43994933 (GRCz11) (1) Details
- Nucleotide change
- ACAGCTCGGGCTCTGACTGTCATCTCTGCGGTTTTGGGGGTCCTGGCTCTCATGATAACCATCGCCGGTGCTCAATGCACCAATTGCATCAACACGGAGTCCATCAAATCCAAAGTGGTCAACGCCGGAG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 130 bp deleted in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CAACTACCGTCACGTTTAAAAAACTCTGACTGCGGGATGCTAATTTTTTTGTTCGGCTGTTCTAACTTGCGATTGGCTGCTGGCAGACGCGCCGCGCTCTGATTGGCTGGAGCCGCTCCTCTTTGTTGCGGGCGCTCTATAACAGCATCCTCCCTTCATTGCAGAGCAGAAACTCCTCAAGCACTTCATCTGAGCGATGTAGAGACACTTCTGCTGCTTCTGACAGATTTAGAGTTTGGAGAAAAAAAACAAAAACAATGGCAAATATGATTTCTGCATGTCTGGAGATTGTTGGACTCTGCTTGACCGTCACCGGGACTCTTTTGGTGATGGTAGCCTGTGGGTTGCCCATGTGGAAAGTGTCCGCCTTCATTGAAGGCAACATTGTGGTGGCGCAAAACATCTGGGACGGGCTGTGGATGTCCTGCGTTGTTCAAAGCACAGGTCAGATGCAATGCAAAATGCACGACTCTGTCTTGGCGCTGACCACTGACCTCCAG
ACAGCTCGGGCTCTGACTGTCATCTCTGCGGTTTTGGGGGTCCTGGCTCTCATGATAACCATCGCCGGTGCTCAATGCACCAATTGCATCAACACGGAGTCCATCAAATCCAAAGTGGTCAACGCCGGAG/- GCGTGATGTACATCGTCGCAGGCTTGTTTGTTCTGATTCCTCTGTGCTGGATGGCCAATAACATCATCTCAGACTTCTACGATCCTCAAGTTCCCTACGCCAAAAAGAGAGAAATCGGAGCTGCGCTGTACATCGGATGGGCAGCATCTGCAATGCTTCTGGTCGGAGGAGCGATTCTGTGTTTCTCCCGTCCACATGATGAGAAATCCACATATCCACTTAAATATATCCCTCCGCCGACAAAAGGCACATCGATCAATGGGGACTATGATAAACGAAACTACGTCTGATCAAGAGGCTAACTATATGGACTTTTGCAGGTGCAAATGGACTTTTAAAACGATAATGCTGATGATACACCGTGGACCTACTTTGGGAAATGATCCCATAGGCAACTAGGTGTTACTAATTAGGGCAATGGGATCCAGATACAATATTGTTGCCTATTCTTAATGGAAAAGCAACTTTACAACATTGCAAAATCGCTCAAAAAGTCGCCC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cldn5bzf3494/zf3494; s843Tg | Complex | Fig. 3 from Yang et al., 2020 | Fig. 3 from Yang et al., 2020 | ||
| cldn5azf3493/zf3493; cldn5bzf3494/zf3494; s843Tg | Complex | Fig. 3 from Yang et al., 2020 | Fig. 3 from Yang et al., 2020 |
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Supplemental Information
- Genotyping protocol
- None
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Yang, Z., Wu, S., Fontana, F., Li, Y., Xiao, W., Gao, Z., Stephan, A., Affolter, M., Belting, H.G., Abdelilah-Seyfried, S., Zhang, J. (2020) The tight junctions protein Claudin-5 limits endothelial cell motility. Journal of Cell Science. 134(1):
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