Genomic Feature
xt53
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 23: 27110409 - 27110418 (GRCz11) (1) Details
- Nucleotide change
- GGTAGGTGGA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 10 bp deleted in Exon 5 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
AAGAAGCTTAATAGCTGGCTGTGCTTTGACAGAAAAGTACAAAAAAGATTCATAAAACAAGTGATAAATGTGGAATTAATGACAACATTTTATCAACAGCGTAGATTAAAATTTGTCCTTTGATCATTTAACAATGTTTTGGACTATTTTCATATTCATAATAATCAACAGCTAATTCAGGCCAAACATGAAACACAAAAAAAAGTGAAAACTTCTCACTTCTTTCCCTAGAACTTGGTATGAAAAGTAATAGTAAAGAACAACTTTACCCACATTTATCATAATTAAATGTGGCATTATTACCATTCTAAAGTCATTATTTTTGCCACAAGCTGACAAAACAACTTGGACTTCATACCTTGAATCGTCTCTTTCTCCCAATTCAGTTCCTCTTGAAGCTGATGAAGTGTTTGGCGGCGATTCTGAATTTCCATAACTTTGGACATTAGATTCTCCACATCAGTCTTTTTCTCCTCCCATGCTTGTTGTGGGATGCCGTT
GGTAGGTGGA/- GGTGCGAAGGGAGGGAACTGCATATTCTTTAAACACACACAAACATCATGAACAACATCATAATAAATACAAATAATGCATTAAACACCTACATTTAAAACTGCTGTAGCATTTTGTCAACAAATCCTAAATGTTGCAAATGTTTTGTACTTACAGTCTGTGATAAAATTAGTCTTTCTTTCCTTAGAATCTCCCGAACTGTCCTCACAAGTTGTAAGGGTTGTGGGTAAAGCACACTCTATAGCACAGAAACAATTCAGCAGGTTACATCAAAAAGAGGAGGGAATACAAACAATGTGCTCTATGTCAACATGGCAGGCTGCCAATAGTAAGACATCCACTGAGTGTATGATAAAAAAGGAAGATTACTTTTAGTTTTGGTATAATTAATACAACATATCTGGACATACTACGCATTTATGTACAGTAGATCATCAAAAAAGAGACTTAGCCATTTTTCATTTCAAGTACCCTCAAATATGAGTTTGGATATGCATATT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| stat6xt53/xt53 | Homozygous | Unknown | Fig. 5  from Denans et al., 2022 | ||
| stat6xt53/xt53 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 4 from Cronan et al., 2021 | Fig. 4 from Cronan et al., 2021 | |
| il10rapsi71/psi71; stat6xt53/xt53 | Complex | Fig. 5 from Denans et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
- Miskolci, V., Tweed, K.E., Lasarev, M.R., Britt, E.C., Walsh, A.J., Zimmerman, L.J., McDougal, C.E., Cronan, M.R., Fan, J., Sauer, J.D., Skala, M.C., Huttenlocher, A. (2022) In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish. eLIFE. 11:
- Cronan, M.R., Hughes, E.J., Brewer, W.J., Viswanathan, G., Hunt, E.G., Singh, B., Mehra, S., Oehlers, S.H., Gregory, S.G., Kaushal, D., Tobin, D.M. (2021) A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization. Cell. 184(7):1757-1774.e14
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