Genomic Feature
re03
- ID
- ZDB-ALT-190814-11
- Name
- re03
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- van Ham Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 18: 18531766 - 18531770 (GRCz11) (1) Details
- Nucleotide change
- CGCCG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
AAAACATAGATTTCTTTCAACGTTTGTTAGATCGATGTTTCATTTACAGTCTCTCAAATGTAAAAGCAAAAAGGTAGTTCCATTAGTATATACAATAGAAACACACTTACAATCATAATTGTCATCCTCTTTTGTGAAGCACTCTTTAAACAGGCAAAGCATGGTCCGATAACAGTTATCAAGGATTGATTTGGGTGTGACTGACTTCCATCCTTTATAATCTTGTTCCGTCAAGTGATCCCAGATGGTTTGTAAGCTCTCTGGACGTTCTCTGACATTCTGAAAGCATACAAAGACACGCTGATTACCACATAACAAATGTCAACAAAGCAAAAATGTCAAGCTGACTGTGAGCCTGATAGCACTAATAGTATGATTTATAATAAGCTGTTATAAAGTCAAATGATATCATTGTTCTAACCTCTTGGTCTTCGTGATTCCCTTCTTTAAAAACCGTCTCAAATTTTTTAAAGAGATTCTCCAGATCAGAGAGGTATTTA
CGCCG/- CGTTGGATGCCTCTCTGGCAGTACCCGTAAGACCTTCTTAATGCCCTGTTGACTCACGTAAAGCCACAAATCCTGGAGATCTCTCGGCAGCACTGGCTCTTCTTCATTACTCGTATTCTAGAGAACACAAAGCGAGAGATTAGACTATAGATATGACGGTTGAAGGAATGAGGAGCAGAGGAACAATAACAATTGGGAAACGTTCAACTTTTTGTGGTTCGCTTGTGATATACAGGCATGTATTAATTTTCAGCATCAGTTTCCAGTAAAATTGTTTAGGCAAGCGGCAACCCTCCGCTCTTCCTCGTGAAGCTAATACGGAAGTAAATGAAACTGCAATTCATCAAAATTCTGCTAGTCCCGGCTCCATAATAGAGCACATTTCTATTGAGCCCACTGTTAAAATGGCCAACTTTACAGCAGAAAAAAAGGTGTTTACAGGCTGTTACAAAAAACGATTTTTGATCATACAGCTATAATAACCCTTCATGATAACTGTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| il34re03/re03 | Homozygous | ♀+/- ♂+/- | 2 figures  from Kuil et al., 2019 | ||
| il34re03/+ | Heterozygous | ♀+/- ♂+/- | Fig. 4 from Kuil et al., 2019 | ||
| il34re03/re03; gl22Tg | Complex | 2 figures from Kuil et al., 2019 | 3 figures from Kuil et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488
- Kuil, L.E., Oosterhof, N., Ferrero, G., Mikulášová, T., Hason, M., Dekker, J., Rovira, M., van der Linde, H.C., van Strien, P.M., de Pater, E., Schaaf, G., Bindels, E.M., Wittamer, V., van Ham, T.J. (2020) Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes. eLIFE. 9:
- Yang, L., Jiménez, J.A., Earley, A.M., Hamlin, V., Kwon, V., Dixon, C.T., Shiau, C.E. (2020) Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration. eLIFE. 9:
- Kuil, L.E., Oosterhof, N., Geurts, S.N., van der Linde, H.C., Meijering, E., van Ham, T.J. (2019) Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain. Disease models & mechanisms. 12(3):
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