Genomic Feature
ca401
- ID
- ZDB-ALT-190716-5
- Name
- ca401
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Vijayan Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 14: 23799102 - 23799108 (GRCz11) (1) Details
- Nucleotide change
- ATGGAGG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 7 bp deleted in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TGGCTGTGCTGAGGCTGGAAGAAGCTGTGCCATTGAGCGTGTTGCTCCCGGAAACCGCAGCCTTCGAGTCCCTGTCTAAATTTGTCGGCAGCTCTGAAAGGAGAGCATCTTCACCTATGGTGGAGAGAAACGCATCGTCAGCAACGTAGAAGTCTGATGGCGATCCATCCAGCTCAAAGTCCTGCAGGAGGTCCAGAGTGTTGTCACTAAAGAGCTTATGATTGCCAACATCAACATCTTTCCCAATGTGTCCAAAGGAATCTTGGTCAAGGTCCATATCGCCTTTAATCATGGGAGAAAAGTCCTCTGTTTTTAAGGGGAAAAGATTGGGATCGACTCCACCAATCAGGGAATCCATTGAGGGAGAGGGGTTGTTAAGGTCTGCAATGCTGGCCTCCAGACCTGAAAGACTGTCACCCAAAGTGAAGGGGACCAAGGTCTGCTGTTGCAGGGCCCTCTGCTCCTTCCCAAGCAGTTTGAGTTCGGAATCGTCGCCAAAG
ATGGAGG/- ACACCGAGCTGGTGTGCTCCTCCAGAGTGGGCGAATTGCTCAGGCCATTGGGAATGTCCCCAGAAACTGGCTGCATCATTGGACCGGCTTGAGGAACCATAGATGTAGGGGCCACAGACATGGTGCTTTGTATTCTTCTTGGTAATATCCCCTCAGTTGCTCGTTTGTTGTAATCCAATGTATTTAAACGCTCATCTCGCTTTTTGCCATTCTCCAGTCCTCCTTGATCCATTTTGCATTACTGTGGTAAAACACAACACAACATTGCTGAAAAACACAGTTAACCGAAAGTAATAAACATGATTAAAGAGATAAAGACAGACAAAAATGCAAAAACTAAAACTAACGTTCCTTCCCTCAGGTCATCTACCCGACTCTCTGCAAACTATTTGGAAATTTAAACATATCCTGGCTGTTTTGTTTTTTGATTATTTTCTCTCTGCTAGATTTGAATATTCACACTCACAGCTATAAAATACAGATTTCTACAGATATGTGAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| nr3c1ca401/ca401 | Homozygous | Unknown | 9 figures from 3 publications | 4 figures from 2 publications | |
| nr3c1ca401/ca401 | Homozygous | ♀+/- ♂+/- | 2 figures from Faught et al., 2019 | 3 figures from Faught et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Nipu, N., Antomagesh, F., Faught, E., Vijayan, M.M. (2022) Glucocorticoid receptor activation reduces food intake independent of hyperglycemia in zebrafish. Scientific Reports. 12:15677
- Faught, E., Vijayan, M.M. (2021) Coordinated action of CRH and cortisol shapes acute stress-induced behavioural response in zebrafish. Neuroendocrinology. 112(1):74-87
- Das, C., Faught, E., Vijayan, M.M. (2020) Cortisol rapidly stimulates calcium waves in the developing trunk muscle of zebrafish. Molecular and Cellular Endocrinology. 520:111067
- Faught, E., Santos, H.B., Vijayan, M.M. (2020) Loss of the glucocorticoid receptor causes accelerated ovarian ageing in zebrafish. Proceedings. Biological sciences. 287:20202190
- Faught, E., Vijayan, M.M. (2019) Loss of the glucocorticoid receptor in zebrafish improves muscle glucose availability and increases growth. American journal of physiology. Endocrinology and metabolism. 316(6):E1093-E1104
- Faught, E., Vijayan, M.M. (2019) Postnatal triglyceride accumulation is regulated by the mineralocorticoid receptor under basal and stress conditions. The Journal of physiology. 597(19):4927-4941
- Faught, E., Vijayan, M.M. (2019) Glucocorticoid and mineralocorticoid receptor activation modulates postnatal growth. The Journal of endocrinology. 244(2):261-271
- Faught, E., Vijayan, M.M. (2018) The mineralocorticoid receptor is essential for stress axis regulation in zebrafish larvae. Scientific Reports. 8:18081
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