Genomic Feature
re01
- ID
- ZDB-ALT-180807-1
- Name
- re01
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- van Ham Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 21: 43857451 - 43857454 (GRCz11) (1) Details
- Nucleotide change
- ACCG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted in Exon 3 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
ACATATACTACATACAATTTAGCTTACCCAATTCACCTATAGCGCATGTGTTTGGATTGTGGGGGAAACTGGAGCTCCCGGAGGAAACCCACGTGAACACGGGGAGAACATGCAAACTCCACACAGATTCACCAACTGACCTAGCTGGGGCTTGAACCAGCAACTTTCTTGCTGTGAGGCGATTGTGCTACCCACTGCCCCACCGTGCTCAACTAACTTTACTTTCTTCTTAATGGTGTTCTTGTCAGTTTTTTTTTCAGTTTGCTGAAATATCTGTATGTTTCTCTAAAACAGATCCCGACAAAGCCTTTACTACGTCTCAAACCCGAGTTATAGTCATAAAAGAAGGCTCGAGCTTCTTGCTGGACTGCTTGCTGACAAATCCAGCAGGGACAGAGTTTTCGCTCCAGATGACAAACGGATCCGCTGTTCCTCCTGGGATGAATTATACTGCGGATCCCAGACGCGGCATACTGATACCAAACCTTCAGCCGAGCTAC
ACCG/- GAGATTACGTCTGTATGGTGAACATGAGCGGAGTCCAATGGAAATCAAAAGTCTTCCAAATCACCGTCATAAAAAGTGAGTCTGTTTTCTAAAACCCTCAGCTGGAGTCAAGATTATTCGCCCTCTTGTGAATTACTCAACCCAGGCTCATTCTGAAAACGTAGCCCCGCGGACGTTTCTGGAGACCGCGATTTACGTGGCCGGAGGTACGTATGGCCGCATTTAGTTTTTTTCAAGCGACGTTGCGGGGCGCCGCTCCTCTTCATGCTCGCCGGCTGGGCTGACGGCTCGCCTCCTCCGTGTGGAGGGCTTTCCCGGCGCAACCAGTTTGTCCGGTTAGCTCTTCGTGTTACATCGGCGGAGCGGAGGAGGAGGAGCCGGCCGGGTTCGATGACCGGGTTCAAGTCCAGGTAGGAGTAGTTCCAGAAATCAGGTAAGACAAAAAACAGAATCCAAAAAATGAAGGGAACGAGTTCGTAATGGGGTGAGAATGCGGCGAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| csf1rbre01/re01 | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | 2 figures from Ferrero et al., 2020 | |
| csf1rbre01/re01 | Homozygous | Unknown | 3 figures from Berdowski et al., 2022 | Fig. 3 from Berdowski et al., 2022 | |
| csf1rbre01/re01; gl22Tg | Complex | Fig. 2 from Berdowski et al., 2022 | Fig. 2 from Berdowski et al., 2022 | ||
| csf1rbre01/re01; gl22Tg; s898Tg; sd5Tg | Complex | 2 figures from Ferrero et al., 2020 | |||
| csf1rbre01/re01; gl22Tg; sd5Tg | Complex | Fig. 5 from Ferrero et al., 2020 | |||
| csf1rbre01/re01; ncv6Tg/ncv6Tg | Complex | ||||
| csf1rbre01/re01; re10Tg | Complex | Fig. 7 from Berdowski et al., 2022 | Fig. 7 from Berdowski et al., 2022 | ||
| csf1rbre01/re01; ue2Tg | Complex | Fig. 4 from Berdowski et al., 2022 | Fig. 4 from Berdowski et al., 2022 | ||
| csf1rbre01/re01; vu234Tg | Complex | Fig. 4 from Berdowski et al., 2022 | Fig. 4 from Berdowski et al., 2022 | ||
| csf1raj4e1/j4e1; csf1rbre01/re01 | Complex | Fig. 3 from Tsarouchas et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Rutherford, H.A., Candeias, D., Duncan, C.J.A., Renshaw, S.A., Hamilton, N. (2024) Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model. Proceedings of the National Academy of Sciences of the United States of America. 121:e2321496121e2321496121
- Bravo, P., Liu, Y., Draper, B.W., Marlow, F.L. (2023) Macrophage activation drives ovarian failure and masculinization in zebrafish. Science advances. 9:eadg7488eadg7488
- Djannatian, M., Radha, S., Weikert, U., Safaiyan, S., Wrede, C., Deichsel, C., Kislinger, G., Rhomberg, A., Ruhwedel, T., Campbell, D.S., van Ham, T., Schmid, B., Hegermann, J., Möbius, W., Schifferer, M., Simons, M. (2023) Myelination generates aberrant ultrastructure that is resolved by microglia. The Journal of cell biology. 222(3):
- Palsamy, K., Chen, J.Y., Skaggs, K., Qadeer, Y., Connors, M., Cutler, N., Richmond, J., Kommidi, V., Poles, A., Affrunti, D., Powell, C., Goldman, D., Parent, J.M. (2023) Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 71(11):2642-2663
- Berdowski, W.M., van der Linde, H.C., Breur, M., Oosterhof, N., Beerepoot, S., Sanderson, L., Wijnands, L.I., de Jong, P., Tsai-Meu-Chong, E., de Valk, W., de Witte, M., van IJcken, W.F.J., Demmers, J., van der Knaap, M.S., Bugiani, M., Wolf, N.I., van Ham, T.J. (2022) Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy. Acta Neuropathologica. 144(2):211-239
- Dai, Y., Wu, S., Cao, C., Xue, R., Luo, X., Wen, Z., Xu, J. (2022) Csf1rb regulates definitive hematopoiesis in zebrafish. Development (Cambridge, England). 149(16)
- Hason, M., Mikulasova, T., Machonova, O., Pombinho, A.R., van Ham, T.J., Irion, U., Nüsslein-Volhard, C., Bartunek, P., Svoboda, O. (2022) M-CSFR/CSF1R signaling regulates myeloid fates in zebrafish via distinct action of its receptors and ligands. Blood advances. 6(5):1474-1488
- Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119
- Cunha, M.I., Su, M., Cantuti-Castelvetri, L., Müller, S.A., Schifferer, M., Djannatian, M., Alexopoulos, I., van der Meer, F., Winkler, A., van Ham, T.J., Schmid, B., Lichtenthaler, S.F., Stadelmann, C., Simons, M. (2020) Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. The Journal of experimental medicine. 217(5):
- Ferrero, G., Miserocchi, M., Di Ruggiero, E., Wittamer, V. (2020) A csf1rb mutation uncouples two waves of microglia development in zebrafish. Development (Cambridge, England). 148(1):
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