Genomic Feature
ul2
- ID
- ZDB-ALT-171009-3
- Name
- ul2
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Angrand Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 24: 17349242 - 17349246 (GRCz11) (1) Details
- Nucleotide change
- AGTCT/CATGCGAAAAACATGCGAAAGACATGC
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 27 bp inserted / 5 bp deleted in Exon 2 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
GGTAAATCTTGAAACCAGTTATTTTGCCATGCCTAAGTGTGCCTGCATATGCTGAAAACACCAAACGCATAATGTTAGGAAAAAGTGTGTGTAGTAAATGAAAGTTCATTAACACTTACATGAATAGGTAGAGCATGAAAACGTATATGGTATGGTTGTTGCAGTTCACAGACTCAACAGTTTGAATAGATGTGCACTCCTACGTTTGATACAATTGTTTACACTTTTGTCACATTCTACATTATGCAGCTAATTCAGTTTTTAGAGATGGATTTTAGAATTCAGTCATTACCATCATGGACATCTTTGGGTCCTATGTTTATTTGTAGTAGTTTTCAATCATATACCAAAGTCAAAAGGAAAACCACCTAACCTTAATGTTGAATGGTTCTATATTAATCTAAAGTGAAATCTAAAACTGTACTCTGTCTATAGGGAAACCATGGGATTGACCGGGAGGAAATCGGAGAAGGGTCCTGTTTGCTGGAGGCGGCGAGTGA
AGTCT/CATGCGAAAAACATGCGAAAGACATGC GAGTACATGCGGCTGCGGCAGCTCAAACGCTTCAGGAGGGCAGACGAGGTCAAGGTAATCCATGGGCTAGTACAGCAGACATACTGCTGCTTGTGTAGAGTTTGGTGTTGGTAATGTTTTAGTTTTCACATAATGAGTCCAGTTGCATGTGTGTAAAACACAAATGAATCAAAGTTTTATTAGAACAACCATGTTGACTTTTTTTGTGTGTGTGAACGTCCTGTAATTGCTACGTATTTTCTTACTGAACAGAGCATGTTCAGCTCCAACAGACAAAAAATATTGGAGCGTACTGACATCTTAAATCAGGAATGGAAACTGAGGCGGATACAGCCTGTTCATATTATGACACCTGTGAGCTCCTTGCGTGGAACCAGAGAGGTTAGATCAATCTCGTTTCTGTTTTTTAATATATGTCCGTTAATATTTTATTGTTAAATGCATTATTGTTTTGGCTGCACAGTGTTAAAAGTGAAAGGGTCATCATTTTCTTTGCCTGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ezh2ul2/ul2 | Homozygous | ♀+/- ♂+/- | 8 figures from 2 publications | 2 figures from Dupret et al., 2017 | |
| ezh1ul3/ul3; ezh2ul2/ul2 | Complex | Fig. 7 from Völkel et al., 2019 | |||
| ezh1ul3/ul3; ezh2ul2/ul2 | Complex | Fig. 7 from Völkel et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- San, B., Rougeot, J., Voeltzke, K., van Vegchel, G., Aben, M., Andralojc, K.M., Flik, G., Kamminga, L.M. (2019) The ezh2(sa1199) mutant zebrafish display no distinct phenotype. PLoS One. 14:e0210217
- Völkel, P., Bary, A., Raby, L., Chapart, A., Dupret, B., Le Bourhis, X., Angrand, P.O. (2019) Ezh1 arises from Ezh2 gene duplication but its function is not required for zebrafish development. Scientific Reports. 9:4319
- Dupret, B., Völkel, P., Follet, P., Le Bourhis, X., Angrand, P.O. (2018) Combining genotypic and phenotypic analyses on single mutant zebrafish larvae. MethodsX. 5:244-256
- Dupret, B., Völkel, P., Vennin, C., Toillon, R.A., Le Bourhis, X., Angrand, P.O. (2017) The histone lysine methyltransferase Ezh2 is required for maintenance of the intestine integrity and for caudal fin regeneration in zebrafish. Biochimica et biophysica acta. 1860(10):1079-1093
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