Genomic Feature
lv2
- ID
- ZDB-ALT-170117-12
- Name
- lv2
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Darras Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 17: 16875100 - 16875101 (GRCz11) (1) Details
- Nucleotide change
- -/CTAA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp inserted (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
AGAGGCAAAATAACGTCAGAGACTTTTTGGCACAAAAATTGGATGAGTTATACTTGTGTTTACAGTTGTGTGGTAAAGTTCAAATGCTCCTACAATGTAAGAGAATGGCATTATCATAAGCATCTTACTACAAACAAAAATCCAGCGTGAGATCAGCAAGATTATAAGCTCTACTTTTTCCATAAGATGCTTAAAAGTTCTTACAGATGGTGTTAGAAGGGGAAAGAACAAAACCTCATTATCAGTTTAGAGCAGTGACAAAGCCCTCAAGAATATGAAGGATGTTTTTAATACTCATGCAACTGTGAATGTGAAATGTCAAACCTGGTGACATCACATAAGTATCCATAACAACAGAGGCCAATAAACCCAGCTAAAGTGGAATAGTTTTCAGTGTAGTCATGCCTCAACTTTGGTTGGCCATGAGCCAGTGCTCAAATGTATTAACATGTTGATGTTGGATTGTTTTGTTCAGGTGAAATTGGGCGAAGCTGCTCCAAA
-/CTAA CTCTAAGGTGGTGAAAGTCACTGGCATCAATAGATGCTGGAGCATCAGCGGTAAGACCCACAACCAGTGCCACCTGCTGGACTTTGAGTCTCCTGATCGCCCGTTAGTGGTCAACTTCGGTTCGGCCACTTGACCCCCCTTTATAAGCCAGCTGCCGGTCTTCCGGCGGATGGTGGAGGAATTTTCAGATGTGGCAGATTTCCTGCTGGTCTACATCGATGAGGCTCACCCTTCAGACGGCTGGGTGGGTCCTCCCATGGAGAACTTTTCGTTTGAAGTGAGGAAACACCGAAATCTGGAGGAGAGGATGTTTGCCGCCAGGACACTTCTGGAGCATTTCTCCTTGCCTCCTCAGTGCCAGTTGGTGGCCGATTGCATGGACAATAATGCCAACATAGCCTACGGTGTGTCCTACGAGAGGGTCTGCATCGTGCAGAAGAATAAAATCGCTTACCTTGGGGGTAAGGGTCCATTTTTTTACAACCTTAAAGATGTTCGGAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dio2lv2/lv2 | Homozygous | ♀+/- ♂+/- | 5 figures from Houbrechts et al., 2016 | Fig. 2 from Houbrechts et al., 2016 | |
| dio2lv2/lv2 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 1 from Houbrechts et al., 2019 | 4 figures from Houbrechts et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Houbrechts, A.M., Beckers, A., Vancamp, P., Sergeys, J., Gysemans, C., Mathieu, C., Darras, V.M. (2019) Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish. Endocrinology. 160(11):2759-2772
- Houbrechts, A.M., Delarue, J., Gabriëls, I.J., Sourbron, J., Darras, V.M. (2016) Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility. Endocrinology. 157:3668-81
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