Genomic Feature
s846
- ID
- ZDB-ALT-110620-1
- Name
- s846
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 28963073 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Cryptic Acceptor Splice Site (1)
- Protein Consequence
- None
- Flanking Sequence
-
GTTTACCTACACTGTAAAAAGTGAGTAAACCCATTGCCTTAAAATGATTAAGTTAATGAACTATGTGCATAATTATAAAAAATCAACCTATTTATTTCATTTCTGAATAAAAAGCCTTTTTATATGGTGACAGATGTTGGTGTTTGTCACAGCACTACTCTGTTATTACTGTATACTCTACATATACAGTTTTTCATATTTTCTCGCATAAAACTTGAGTGTTTCTTCTAGAGCGTCCTGACAGCTCCTAATTCTCACTTCAATAGCAGCTAAATAACCAAGCTCAATGCTTTTTTTTTTCTCCGCAGGATCTGAAGTTCATATACGGCCGGTATATCGACATCTCCTCAGAGGAAGAGAGAAACATGTAAGCCCCGCTGTCTCTGCCTCAGGCCCTCCACCATTCACAATCAAAGCCAATGAAAAGCAAACAGCACTCCTGCTTTTTTTTACCTCAGGAGCGTTGAATAAAAGGCGAGCTCTTTATGAACGTTTGTGTT
T/A GCTCCCGTCAGGTTTGATATCGTTTTGATGAAAGAGGGGAGGATGAAAGGTCAGGCCTTCATCGGACTGCCCAGCGAAAGAAGCGCACAGAAGGCCCTGAAGGAAACCAATGGATATGTGCTCAAGGACAAACCTCTGGTGGTGGTATCCTTTGCTTTTTTAGCCATTTAAGCATTGTCTTGTGAAGAGAATACATGCAAATTAGAGCTGCTTTTAGGCATGCTGTCATTTTTAGCTGAAGTTTATGCTTGTGTTTGACTTGTTACACATTGCATTTATTCTAAACGCTTTCTTGTCAAATCAAATCAGGCCTTAACTTATACTTCAGCAATTCGCACGATCTGCAAAGCCTAAACAGGAATCTGCTGACCCGAAGAAAGGAGGGAGAAAACACTGAAGTGGTGGGTTAGAGAATCATTTTGGTACAAACACTTCCTGCATTTAGATTTTTAAAGCTGTGTCTTTTTTGAGTTGTTGAAAAAAGTTTCTTCTGCTCAACG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| rnpc3s846/s846 | Homozygous | ♀+/- ♂+/- | 4 figures  from Markmiller et al., 2014 | ||
| rnpc3s846/s846; gz15Tg | Complex | Fig. 1 from Markmiller et al., 2014 | Fig. 1 from Markmiller et al., 2014 | ||
| rnpc3s846/s846; s854Tg | Complex | Fig. 1 from Markmiller et al., 2014 | Fig. 1 from Markmiller et al., 2014 | ||
| rnpc3s846/+; rnpc3zm00416857Tg/+ | Complex | Fig. S1 from Markmiller et al., 2014 |
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Supplemental Information
- Genotyping protocol
- None
- Bruton, F.A., Kaveh, A., Ross-Stewart, K.M., Matrone, G., Oremek, M.E.M., Solomonidis, E.G., Tucker, C.S., Mullins, J.J., Lucas, C.D., Brittan, M., Taylor, J.M., Rossi, A.G., Denvir, M.A. (2022) Macrophages trigger cardiomyocyte proliferation by increasing epicardial vegfaa expression during larval zebrafish heart regeneration. Developmental Cell. 57(12):1512-1528.e5
- Markmiller, S., Cloonan, N., Lardelli, R.M., Doggett, K., Keightley, M.C., Boglev, Y., Trotter, A.J., Ng, A.Y., Wilkins, S.J., Verkade, H., Ober, E.A., Field, H.A., Grimmond, S.M., Lieschke, G.J., Stainier, D.Y., and Heath, J.K. (2014) Minor class splicing shapes the zebrafish transcriptome during development. Proceedings of the National Academy of Sciences of the United States of America. 111(8):3062-3067
- Boglev, Y., Badrock, A.P., Trotter, A.J., Du, Q., Richardson, E.J., Parslow, A.C., Markmiller, S.J., Hall, N.E., de Jong-Curtain, T.A., Ng, A.Y., Verkade, H., Ober, E.A., Field, H.A., Shin, D., Shin, C.H., Hannan, K.M., Hannan, R.D., Pearson, R.B., Kim, S.H., Ess, K.C., Lieschke, G.J., Stainier, D.Y., and Heath, J.K. (2013) Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genetics. 9(2):e1002379
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