Genomic Feature
hg5
Notes
| Comment | Citation |
|---|---|
| hg5 (brca2 Q658X) has a C-to-T point mutation within exon 11 (C1971T) that ... | Shive et al., 2010 |
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr: 15 Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 1971 in Exon 11 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 658 (1)
- Flanking Sequence
-
- Additional Sequence
- None
Fish
Supplemental Information
- Genotyping protocol
- None
- Kouprianov, V.A., Selmek, A.A., Ferguson, J.L., Mo, X., Shive, H.R. (2022) brca2-mutant zebrafish exhibit context- and tissue-dependent alterations in cell phenotypes and response to injury. Scientific Reports. 12:883
- Allen, T.A., Asad, D., Amu, E., Hensley, M.T., Cores, J., Vandergriff, A., Tang, J., Dinh, P.U., Shen, D., Qiao, L., Su, T., Hu, S., Liang, H., Shive, H., Harrell, E., Campbell, C., Peng, X., Yoder, J.A., Cheng, K. (2019) Circulating tumor cells exit circulation while maintaining multicellularity augmenting metastatic potential. Journal of Cell Science. 132(17):
- Mensah, L., Ferguson, J.L., Shive, H.R. (2019) Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model. Journal of oncology. 2019:9218251
- Vierstraete, J., Willaert, A., Vermassen, P., Coucke, P.J., Vral, A., Claes, K.B.M. (2017) Accurate quantification of homologous recombination in zebrafish: brca2 deficiency as a paradigm. Scientific Reports. 7:16518
- White, L.A., Sexton, J.M., Shive, H.R. (2017) Histologic and Immunohistochemical Analyses of Soft Tissue Sarcomas From brca2-Mutant/tp53-Mutant Zebrafish Are Consistent With Neural Crest (Schwann Cell) Origin. Veterinary Pathology. 54(2):320-327
- Shive, H.R., West, R.R., Embree, L.J., Golden, C.D., and Hickstein, D.D. (2014) BRCA2 and TP53 collaborate in tumorigenesis in zebrafish. PLoS One. 9(1):e87177
- Shive, H.R., West, R.R., Embree, L.J., Azuma, M., Sood, R., Liu, P., and Hickstein, D.D. (2010) brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 107(45):19350-19355
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