Genomic Feature
sa16
- ID
- ZDB-ALT-071019-3
- Name
- sa16
- Synonyms
-
- sa0016 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stemple Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 6: 15753550 (GRCz11) (1) Details
- Nucleotide change
- A/C
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>G (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
TCAACTGAGGGATGGATGGTATTAGCCAGGAGGACGTAGAACACAGCAATGACAGGGAAGGGAATGGCAAAGCCAAGCATGAAGAAGCTCATTTGGATGCCAACCGTCCACTCCTTCATGCTTTCCACTGGGTAAACTGCTTTGCAGACGATGGCGTCTGAATGGTCAGATTTCTCAGCCTGAAGGAAGTATATTTCAGGGAGGGCAGCAATGAGAGCCAGCAGCCAAACTCCAACGCAGATTATCTGCCTGGTTCTTCTCTTCCTCTGACTGGGAGTGTCTCCAAAAAGTTTCACAGAGAGATATCGGTCCACACTCATACACGTAAGGAAGAAGATACTGCTGAAGAGGTTGACACTGAAGATCAGGTGTGTAATCTTGCACATGGCACCACCAAATGGCCAGTGGCCGAGCTGAAGCAGAGAACTAATGGAGACTGGAAGAGTTGCCACCACACAAAGGTCAGCGATGGCTAGGTTGAGGATGTACAGGTGAGTCTC
A/C TAACGTGTCCTCTCGGCTCTCACGTTCACCCAAACCACCAGAGCGTTGGCAGCGAGGCCAATGATGAAGAGGAAGATGTAGAGCACAGAGAGGGCGTACAGCAAGGCCCTCTGGCTGAAGGTGCTGTGGCACACTTCCACATGGGAGACATTATCGTCAAGAGTTGAGAAGTTCAGTTCACCCAGTGCATCCAAAATGTCATTGAAATCATTCACGTTCACACTCATCTTGGTCCGTCTTTGTTATCGTCAACACTTCAGTGACCTGAAACAAAAGAGAGAGGCGGTTATGACATGTAGGCAGAATAAAAAACATAAGCAGGGACCAATTAAGCACAGAGGGACGGAAAAGGGATAACAAAGAAAGTTTATTTTAAAAACACACATAATCTGAAACATCTCGAGCGCACCAGGATCTCTCTTCAGGGGGTAGGATCTTGTACTATTTAATAGGATCAATTCCTAAATAGTTATTGTGCATGGGTTTATTTCCCAGGGTTA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| ackr3bsa16/sa16 | Homozygous | ♀+/- ♂+/- | 2 figures  from 2 publications | Fig. 3 from Lewellis et al., 2013 | |
| ackr3bsa16/+ | Heterozygous | Unknown | Fig. 5 from Lewellis et al., 2013 | 2 figures from Lewellis et al., 2013 | |
| ackr3bsa16/+ (AB) | Heterozygous | Unknown | |||
| ackr3bsa16 | Unknown | Unknown | |||
| ackr3bsa16/sa16; sk78Tg; zf106Tg | Complex | Fig. 1 from Venkiteswaran et al., 2013 | |||
| ackr3bsa16/sa16; sk79Tg | Complex | Fig. 4 from Venkiteswaran et al., 2013 | |||
| ackr3bsa16/sa16; zf106Tg | Complex | Fig. 1 from Venkiteswaran et al., 2013 | Fig. 1 from Venkiteswaran et al., 2013 | ||
| ackr3bsa16/sa16; zf511Tg | Complex | Fig. 4 from Donà et al., 2013 | Fig. 4 from Donà et al., 2013 | ||
| ackr3bsa16/sa16; sk77Tg + MO1-ackr3a + MO2-ackr3a | Complex | Fig. 2 from Venkiteswaran et al., 2013 | |||
| ackr3bsa16/sa16; sk78Tg; sk79Tg + MO1-ackr3a + MO2-ackr3a | Complex | Fig. 4 from Venkiteswaran et al., 2013 |
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Supplemental Information
- Genotyping protocol
- None
- Lau, S., Feitzinger, A., Venkiteswaran, G., Wang, J., Lewellis, S.W., Koplinski, C.A., Peterson, F.C., Volkman, B.F., Meier-Schellersheim, M., Knaut, H. (2020) A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration. Nature cell biology. 22(3):266-273
- Wong, M., Newton, L.R., Hartmann, J., Hennrich, M.L., Wachsmuth, M., Ronchi, P., Guzmán-Herrera, A., Schwab, Y., Gavin, A.C., Gilmour, D. (2020) Dynamic Buffering of Extracellular Chemokine by a Dedicated Scavenger Pathway Enables Robust Adaptation during Directed Tissue Migration. Developmental Cell. 52(4):492-508.e10
- Yakulov, T.A., Todkar, A.P., Slanchev, K., Wiegel, J., Bona, A., Groß, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T.B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., de Tullio, P., Jouret, F., Kramer-Zucker, A., Walz, G. (2018) CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nature communications. 9:3660
- Donà, E., Barry, J.D., Valentin, G., Quirin, C., Khmelinskii, A., Kunze, A., Durdu, S., Newton, L.R., Fernandez-Minan, A., Huber, W., Knop, M., and Gilmour, D. (2013) Directional tissue migration through a self-generated chemokine gradient. Nature. 503(7475):285-9
- Lewellis, S.W., Nagelberg, D., Subedi, A., Staton, A., Leblanc, M., Giraldez, A., and Knaut, H. (2013) Precise SDF1-mediated cell guidance is achieved through ligand clearance and microRNA-mediated decay. The Journal of cell biology. 200(3):337-355
- Venkiteswaran, G., Lewellis, S.W., Wang, J., Reynolds, E., Nicholson, C., and Knaut, H. (2013) Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue. Cell. 155(3):674-687
- Staton, A.A., Knaut, H., and Giraldez, A.J. (2011) miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration. Nature Genetics. 43(3):204-211
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