Genomic Feature
sa2
- ID
- ZDB-ALT-070730-8
- Name
- sa2
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Stemple Lab
- Current Source
-
European Zebrafish Resource Center (EZRC)
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Zebrafish International Resource Center (ZIRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 7: 25324630 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- A>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
GAAATTTAAAACAACGAATCAATCTCAAGTTGGACAAGTTCACTCCAAATTTACACTTCAAAAATTTGAATTTAATTGATGAATTCAAGAAATATTGGTCACCGATTTGGATGATTTAAAATGATATACACACATTTAAGATCGATTTGTTATATCCAGCATTCTGTTAATTAAATAGCCGACTATATTTTATTTATTCATTTACTCTACATAAACTTTTAGGGTTGGATTTGTGCTTTTTCGAATAATTGTCGCAGAGAGTCATATCTAACAGAGTAGGTCACTCTCCTAATTTTAGGTTTAACCACTTTATTGCTCATCACTCCAAAGAGATATTTGAGACAAGTCCCCGGACGTTCACAGCCATGCTCTTCGAGAGTTTTGACCTTGTCTCGGCGTTGGCGACGCTGGCTGCGTGTTTAGTGTCCATGGCACTTCTTCTGGCCGTGTCCCAGCAGCTCTGGCAGCTGAGGTGGACCGCAACACGGGACAAGAGCTGC
A/T AGCTGCCCATGCCCAAGGGCTCCATGGGGTTCCCCATCATCGGAGAAACATGCCACTGGTTCTTTCAGGTAAGCGCTCATTCTCCTTGTGCCTTTCCAAGTTTCCAGTCTCCCTGCTGTCGCACGCACAGCGCTCCGGCGCGCCAGACACCGCGGGCTCGGCGCATATAGTTTTTCCTGCAGGTAACTGGGTTGTTAAAGACACTTCAAGAGTAGGATAACGTCCACTAATGCTTTTCGCACGTGTGCACTCGTGAGCAATATTGCGCTTTAAAATAAGAACAGCTTGCAGGTTAGTTATTCCCACGTGTGTAATTTCTTCCGTGCCATATTTCCATGGTGTTAATAAGCTGTCTGTTTTAGATAGCCGTCAGTTTTGTTTAATACAGCCAGTTCTCAATCCACGTGGAACAATCTGTTTGCGGCTGCCAAGGAAGGCGCACTCCGTTCCAGAAATATTGTAGTCCTTGGCTTCCGATGCGCGCGAGAACACAGCCACTG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cyp26b1sa2/sa2 | Homozygous | ♀+/- ♂+/- | 3 figures  from 2 publications | 3 figures from Spoorendonk et al., 2008 | |
| cyp26b1sa2/+ (AB) | Heterozygous | Unknown | Fig. 3 from Gibert et al., 2015 | ||
| cyp26b1sa2 | Unknown | Unknown | |||
| cyp26b1sa2/+; cyp26b1sa3/+ | Complex | Fig. 2 from Spoorendonk et al., 2008 |
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Supplemental Information
- Genotyping protocol
- None
- McGurk, P.D., Swartz, M.E., Chen, J.W., Galloway, J.L., Eberhart, J.K. (2017) In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw. PLoS Genetics. 13:e1007112
- Gibert, Y., Samarut, E., Pasco-Viel, E., Bernard, L., Borday-Birraux, V., Sadier, A., Labbé, C., Viriot, L., Laudet, V. (2015) Altered retinoic acid signalling underpins dentition evolution. Proceedings. Biological sciences. 282(1802)
- Laue, K., Pogoda, H.M., Daniel, P.B., van Haeringen, A., Alanay, Y., von Ameln, S., Rachwalski, M., Morgan, T., Gray, M.J., Breuning, M.H., Sawyer, G.M., Sutherland-Smith, A.J., Nikkels, P.G., Kubisch, C., Bloch, W., Wollnik, B, Hammerschmidt, M., and Robertson, S.P. (2011) Craniosynostosis and Multiple Skeletal Anomalies in Humans and Zebrafish Result from a Defect in the Localized Degradation of Retinoic Acid. American journal of human genetics. 89(5):595-606
- Laue, K., Jänicke, M., Plaster, N., Sonntag, C., and Hammerschmidt, M. (2008) Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development. Development (Cambridge, England). 135(22):3775-3787
- Spoorendonk, K.M., Peterson-Maduro, J., Renn, J., Trowe, T., Kranenbarg, S., Winkler, C., and Schulte-Merker, S. (2008) Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton. Development (Cambridge, England). 135(22):3765-3774
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