Genomic Feature
hu745
- ID
- ZDB-ALT-050914-2
- Name
- hu745
- Synonyms
-
- mcr (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- ENU
- Lab of Origin
- Clevers Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 10: 1887755 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Gln>Stop at position 605 (1)
- Flanking Sequence
-
AAGAAGAACAGCTCGAGGAACAAACTCCCAGCTACAGCATGAAATACACTGAGGATCATCATGTAGAGCAGCCTATTGATTACAGTTTGAAGTACTCGGAAGCTCCTTCCAAGAAGGGCATGTTTAGTCATTCAAAGACGTCTTCTGCACAGAGTTCTGCCAAAGAACATTTAAGCCAGGATAGTTCTTCTTCTGTGGCATCTTTAAAGAATCAGGGCAGGCAAAAGCAGCTCCACCCTTCATCTGCTCAAAGCAGATCCGGACCAACAAGAGCAGTTCAAAAGAACCCAACATGCAAGGCTCCCACAATAAATCAAGAAACTTTACAGACCTATTGTGTGGAAGATACTCCCATTTGTTTTTCACGTGGTAGCTCTTTATCGTCGTTGTCTTCAGAGGAGGATGAAATGGAGAGCTGTAAGCGTAATGTCAACTCGGCCAGTAACTACCCAACTTTACCTATATCAGAAAAACAATCCACTAATAATGTTGCAGCTGAC
C/T AACGCACATCTGAGAGCCAATCATCAGTCCATTATGTTCGCGCCAAGCCTCCACGACATCATTTAGGACATGGTGATGGTTCCAGGCATCATAAAACGGTGGAGTTTTCATCAGGGGCTAAATCACCTTCTAAAAGTGGTGCCCAAACACCTAAAAGTCCCCCTGAGCATTATGTACAGGAGACTCCTCTAATGTTCAGCAGATGCACTTCAGTCAGCTCCCTTGACAGTTTTGAGAGTCATTCCATTGCCAGTTCTGTGCAGAGTGAGCCATGCAGTGGGATGGTCAGTGGCATCATCAGTCCGAGTGACTTACCTGATAGTCCTGGACAAACAATGCCTCCAAGTCGCAGCAAGACACCACCACCTCCACCTCCGCGGTCCACGTCAGTAAAACAGAAAGTTACAGTGCCACCCCACACTGAAAAACATGATTTGGCGCCAAGACATGCAGTTGTAAGTGCTGCCGTGCAAAAAGTGCAAGTTTTGCCAGATAATGAT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| apchu745/hu745 | Homozygous | ♀+/- ♂+/- | 24 figures  from 12 publications | 31 figures from 17 publications | |
| apchu745/hu745 | Homozygous | Unknown | 12 figures from 4 publications | 27 figures from 9 publications | |
| apchu745/+ | Heterozygous | ♀+/- ♂+/- | 3 figures from Haramis et al., 2006 | Fig. 3 from Haramis et al., 2006 | |
| apchu745/+ | Heterozygous | Unknown | 6 figures from Goessling et al., 2008 | 4 figures from Goessling et al., 2008 | |
| apchu745/hu745; as3Tg | Complex | Fig. 1 from Goessling et al., 2008 | Fig. 1 from Goessling et al., 2008 | ||
| apchu745/hu745; ia5Tg | Complex | ||||
| apchu745/hu745; ia28Tg | Complex | Fig. 7. from Peron et al., 2020 | |||
| apchu745/hu745; s356tTg | Complex | Fig. 1 from Aman et al., 2008 | |||
| apchu745/hu745; s854Tg | Complex | Fig. 4 from Goessling et al., 2008 | |||
| apchu745/hu745; zf106Tg | Complex | 2 figures from Aman et al., 2008 |
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Supplemental Information
- Genotyping protocol
- None
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Peron, M., Dinarello, A., Meneghetti, G., Martorano, L., Facchinello, N., Vettori, A., Licciardello, G., Tiso, N., Argenton, F. (2020) The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent. Development (Cambridge, England). 147(12):
- Delacruz, R.G.C., Sandoval, I.T., Chang, K., Miller, B.N., Reyes-Uribe, L., Borras, E., Lynch, P.M., Taggart, M.W., Hawk, E.T., Vilar, E., Jones, D.A. (2019) Functional characterization of CNOT3 variants identified in familial adenomatous polyposis adenomas. Oncotarget. 10:3939-3951
- Tang, D., He, Y., Li, W., Li, H. (2019) Wnt/β-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast. Experimental & molecular medicine. 51:58
- Spikol, E.D., Glasgow, E. (2018) Separate roles for Med12 and Wnt signaling in regulation of oxytocin expression. Biology Open. 7(3)
- Kozlovskaja-Gumbrienė, A., Yi, R., Alexander, R., Aman, A., Jiskra, R., Nagelberg, D., Knaut, H., McClain, M., Piotrowski, T. (2017) Proliferation-independent regulation of organ size by Fgf/Notch signaling. eLIFE. 6
- Sandoval, I.T., Delacruz, R.G., Miller, B.N., Hill, S., Olson, K.A., Gabriel, A.E., Boyd, K., Satterfield, C., Remmen, H.V., Rutter, J., Jones, D.A. (2017) A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).. eLIFE. 6
- Ahuja, S., Dogra, D., Stainier, D.Y., Reischauer, S. (2016) Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development. Developmental Biology. 412(1):71-82
- He, Y., Cai, C., Sun, S., Wang, X., Li, W., Li, H. (2016) Effect of JNK inhibitor SP600125 on hair cell regeneration in zebrafish (Danio rerio) larvae. Oncotarget. 7(32):51640-51650
- Pestel, J., Ramadass, R., Gauvrit, S., Helker, C., Herzog, W., Stainier, D.Y. (2016) Real-time 3D visualization of cellular rearrangements during cardiac valve formation. Development (Cambridge, England). 143:2217-27
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