Genomic Feature
hi3736aTg
- ID
- ZDB-ALT-050809-8
- Name
- hi3736aTg
- Synonyms
-
- hi3736a (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the minus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 14: 30795779 - 30795780 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| cfl1hi3736aTg/hi3736aTg (AB) | Homozygous | ♀+/- ♂+/- | Fig. 1  from Ashworth et al., 2010 | ||
| cfl1hi3736aTg/+ (AB) | Heterozygous | Unknown | |||
| cfl1hi3736aTg/+ (AB/TU) | Heterozygous | Unknown | |||
| cfl1hi3736aTg | Unknown | Unknown | Fig. for (hi3736a) from Phenotype Annotation (1994-2006) |
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Supplemental Information
- Genotyping protocol
- None
- Fukuda, R., Gunawan, F., Ramadass, R., Beisaw, A., Konzer, A., Mullapudi, S.T., Gentile, A., Maischein, H.M., Graumann, J., Stainier, D.Y.R. (2019) Mechanical Forces Regulate Cardiomyocyte Myofilament Maturation via the VCL-SSH1-CFL Axis. Developmental Cell. 51(1):62-77.e5
- Ashworth, S., Teng, B., Kaufeld, J., Miller, E., Tossidou, I., Englert, C., Bollig, F., Staggs, L., Roberts, I.S., Park, J.K., Haller, H., and Schiffer, M. (2010) Cofilin-1 inactivation leads to proteinuria--studies in zebrafish, mice and humans. PLoS One. 5(9):e12626
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