Genomic Feature
hi3394aTg
- ID
- ZDB-ALT-040827-10
- Name
- hi3394aTg
- Synonyms
-
- hi3394a (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 9: 32176634 - 32176635 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Intron 1 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sf3b1hi3394aTg/hi3394aTg | Homozygous | Unknown | text only from Amsterdam et al., 2004 | Fig. 3  from An et al., 2012 | |
| sf3b1hi3394aTg/hi3394aTg | Homozygous | ♀+/- ♂+/- | 6 figures from 2 publications | 7 figures from 2 publications | |
| sf3b1hi3394aTg/hi3394aTg (AB) | Homozygous | ♀+/- ♂+/- | 2 figures from Sorrells et al., 2018 | Fig. 2 from Sorrells et al., 2018 | |
| sf3b1hi3394aTg/+ (AB) | Heterozygous | Unknown | |||
| sf3b1hi3394aTg/+ (AB/TU) | Heterozygous | Unknown | |||
| sf3b1hi3394aTg | Unknown | Unknown | Fig. for (hi3394a) from Phenotype Annotation (1994-2006) | ||
| sf3b1hi3394aTg/hi3394aTg; la781Tg | Complex | 2 figures from De La Garza et al., 2019 | Fig. 1 from De La Garza et al., 2016 | ||
| sf3b1hi3394aTg/hi3394aTg; nz50Tg | Complex | Fig. 2 from De La Garza et al., 2016 | |||
| sf3b1hi3394aTg/hi3394aTg; pd27Tg; zf169Tg | Complex | Fig. 4 from De La Garza et al., 2016 | |||
| sf3b1hi3394aTg/hi3394aTg; um14Tg | Complex | Fig. 5 from De La Garza et al., 2016 |
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Supplemental Information
- Genotyping protocol
- None
- Potts, K.S., Cameron, R.C., Metidji, A., Ghazale, N., Wallace, L., Leal-Cervantes, A.I., Palumbo, R., Barajas, J.M., Gupta, V., Aluri, S., Pradhan, K., Myers, J.A., McKinstry, M., Bai, X., Choudhary, G.S., Shastri, A., Verma, A., Obeng, E.A., Bowman, T.V. (2022) Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition. Cell Reports. 41:111825111825
- De La Garza, A., Cameron, R.C., Gupta, V., Fraint, E., Nik, S., Bowman, T.V. (2019) The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish. Blood advances. 3:2093-2104
- Sorrells, S., Nik, S., Casey, M., Cameron, R.C., Truong, H., Toruno, C., Gulfo, M., Lowe, A., Jette, C., Stewart, R.A., Bowman, T.V. (2018) Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Disease models & mechanisms. 11(2)
- De La Garza, A., Cameron, R.C., Nik, S., Payne, S.G., Bowman, T.V. (2016) The Spliceosomal Component Sf3b1 is Essential for Hematopoietic Differentiation in Zebrafish. Experimental hematology. 44(9):826-837.e4
- An, M., and Henion, P.D. (2012) The zebrafish sf3b1(b460) mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development. The International journal of developmental biology. 56(4):223-237
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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