Genomic Feature
hi1779Tg
- ID
- ZDB-ALT-040805-4
- Name
- hi1779Tg
- Synonyms
-
- hi1779 (1)
- Affected Genomic Region
- Construct
- Type
- Allele caused by Transgenic insertion (1)
- Protocol
- embryos treated with DNA
- Lab of Origin
- Hopkins Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
| Comment | Citation |
|---|---|
| The construct was inserted on the plus strand of the genome. The gene in which ... | ZFIN Curated Data |
| A 6-kb retroviral insertion at base 553 in the coding sequence leads to a ... | Lowery et al., 2007 |
Variants
- Variant Type
- Transgenic Insertion
- Variant Location
- Chr 19: 40026771 - 40026772 (GRCz11) (1) Details
- Nucleotide change
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- Insertion in Exon 1 (1)
- Transcript Consequence
- None
- Protein Consequence
- Polypeptide Truncation: at position 197 (1)
- Flanking Sequence
- None
- Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sfpqhi1779Tg/hi1779Tg | Homozygous | Unknown | text only from Amsterdam et al., 2004 | ||
| sfpqhi1779Tg/hi1779Tg (AB) | Homozygous | ♀+/- ♂+/- | Fig. 1  from Sorrells et al., 2018 | ||
| sfpqhi1779Tg/hi1779Tg (AB/TU) | Homozygous | ♀+/- ♂+/- | 2 figures from Barresi et al., 2010 | Fig. 3 from Barresi et al., 2010 | |
| sfpqhi1779Tg/+ (AB) | Heterozygous | Unknown | |||
| sfpqhi1779Tg/+ (AB/TU) | Heterozygous | Unknown | |||
| sfpqhi1779Tg | Unknown | Unknown | Fig. for (hi1779) from Phenotype Annotation (1994-2006) | ||
| sfpqhi1779Tg (AB/TU) | Unknown | Unknown |
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Supplemental Information
- Genotyping protocol
- None
- Sorrells, S., Nik, S., Casey, M., Cameron, R.C., Truong, H., Toruno, C., Gulfo, M., Lowe, A., Jette, C., Stewart, R.A., Bowman, T.V. (2018) Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Disease models & mechanisms. 11(2)
- Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618
- Lowery, L.A., Rubin, J., and Sive, H. (2007) whitesnake/sfpq is required for cell survival and neuronal development in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(5):1347-1357
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
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