Genomic Feature
p106re
- ID
- ZDB-ALT-040224-4
- Name
- p106re
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Mullins Laboratory
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 2: 27858476 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A in Exon 6 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Cys>Stop (1)
- Flanking Sequence
-
GAGTCTCCAAGAGTGTCCAAAAGGAAGTGTTGCAGTAGGCATGCGCTGCCCTCTTGTGGGCATCATTGTGCCAAACACAGACACAGGAAGCTGCTTTGTGAAGGCCAGGAGAGCTGTGATCTACGTGAGCAGGCTCGAGTGCATCCCAAAGGAGAGTGCTGTGAGGAGTATGGTGCTCTGGCTAAAGCAGATAAGAGAATTCAAAAGGGTGCCTTGTGCAGGCCTTGTATTGGTAAGGTTTTTGTATTTTTGCATTTTAATGCTGTCATGAGGTGGTCAGCTCATGCAAAATTATTTTTAGAGCAACAATGGAGAGAGGGGGTTGTGTCTGACCAAGAGAATTGGGCGAGCTGTGGTGCCAAACCGAGGTCTTGGAGGCAAGTTACTGGACCTCAGGATCAAGGTAGGATATGTGTGTGTCTCTGTGTGAAGTATGCTTTTGTTTTATTTTTTTTTTTTTTTCTCCCCAAAGGGAGAACTCCATTGAGAAGGTCGACTTG
T/A AAATCAATCCACCAGCAAAGGCCAAGAAGTGAATACAATGACTATGATGAGACCGAATTTACCTACTGCCAGAGGGGCAGAGGTATGTTGAGCAGTTTAAAATGTTAAACTTTTTTTTTTTTTTTCTTTTTTTTTTTCTTCTTTGTTCTTATTTGTGCAAATTGTTCCTTCAGGTTCTATGAAGAAAAGAGGCTCAAGATACTAAACCATTATGCACTGCTGTAATACTTAATGTATTACCCTAAACTTGTGTAAAATGCACTTCACTATAAATGTACACATGGACACTGTTCTTGACTGTATGTAAATGAAAGGTATGACAGTGATGTACACCTTGCTGCATTTCCAGTGCTCAAGTTAACTTTTTTTGGGTGCTGTGCATTCATCTTAATATTATGCTGAAACTGGTCTCACTGTACCAGACCTTGACCTATGCCTACAAGGCCTTTCTAATGTGTCTTGATCTGGGAGGTGTAGATCATTTCTGAAAAAGGGGCTCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| bucp106re/p106re | Homozygous | Unknown | 7 figures  from 2 publications | 5 figures from 3 publications | |
| bucp106re/p106re | Homozygous | ♀+/- ♂+/- | 4 figures from 3 publications | 5 figures from 4 publications | |
| bucp106re/+ | Heterozygous | Unknown | Fig. 4 from Heim et al., 2014 | Fig. 5 from Heim et al., 2014 | |
| bucp106re/+ | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Bontems et al., 2009 | ||
| bucp106re/+ | Heterozygous | ♀-/- ♂+/+ | Fig. 7 from Roovers et al., 2018 | ||
| bucp106re | Unknown | ♀-/- | Fig. 3 from Heim et al., 2014 | ||
| bucp106re (AB/TU) | Unknown | Unknown | |||
| bucp106re/p106re; ae6Tg | Complex | ||||
| bucp106re/p106re; ae7Tg | Complex | Fig. 4 from Heim et al., 2014 | |||
| bucp106re/p106re; ae8Tg | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Xia, P., Gütl, D., Zheden, V., Heisenberg, C.P. (2019) Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity. Cell. 176(6):1379-1392.e14
- Dingare, C., Niedzwetzki, A., Klemmt, P.A., Godbersen, S., Fuentes, R., Mullins, M.C., Lecaudey, V. (2018) The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish. Development (Cambridge, England). 145(22):
- Krishnakumar, P., Riemer, S., Perera, R., Lingner, T., Goloborodko, A., Khalifa, H., Bontems, F., Kaufholz, F., El-Brolosy, M.A., Dosch, R. (2018) Functional equivalence of germ plasm organizers. PLoS Genetics. 14:e1007696
- Roovers, E.F., Kaaij, L.J.T., Redl, S., Bronkhorst, A.W., Wiebrands, K., de Jesus Domingues, A.M., Huang, H.Y., Han, C.T., Riemer, S., Dosch, R., Salvenmoser, W., Grün, D., Butter, F., van Oudenaarden, A., Ketting, R.F. (2018) Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification. Developmental Cell. 46:285-301.e9
- Escobar-Aguirre, M., Zhang, H., Jamieson-Lucy, A., Mullins, M.C. (2017) Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. PLoS Genetics. 13:e1006983
- Riemer, S., Bontems, F., Krishnakumar, P., Gömann, J., Dosch, R. (2015) A functional Bucky ball-GFP transgene visualizes germ plasm in living zebrafish. Gene expression patterns : GEP. 18(1-2):44-52
- Ge, X., Grotjahn, D., Welch, E., Lyman-Gingerich, J., Holguin, C., Dimitrova, E., Abrams, E.W., Gupta, T., Marlow, F.L., Yabe, T., Adler, A., Mullins, M.C., Pelegri, F. (2014) Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. PLoS Genetics. 10(6):e1004422
- Heim, A.E., Hartung, O., Rothhämel, S., Ferreira, E., Jenny, A., and Marlow, F.L. (2014) Oocyte polarity requires a Bucky ball-dependent feedback amplification loop. Development (Cambridge, England). 141(4):842-854
- Nojima, H., Rothhämel, S., Shimizu, T., Kim, C.H., Yonemura, S., Marlow, F.L., and Hibi, M. (2010) Syntabulin, a motor protein linker, controls dorsal determination. Development (Cambridge, England). 137(6):923-933
- Bontems, F., Stein, A., Marlow, F., Lyautey, J., Gupta, T., Mullins, M.C., and Dosch, R. (2009) Bucky Ball Organizes Germ Plasm Assembly in Zebrafish. Current biology : CB. 19(5):414-422
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