Genomic Feature
em1
- ID
- ZDB-ALT-030617-2
- Name
- em1
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- spontaneous
- Lab of Origin
- Fritz Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 12: 43664495 - 43664497 (GRCz11) (1) Details
- Nucleotide change
- GCT/C
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp inserted / 3 bp deleted (1)
- Transcript Consequence
- Frameshift (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TCATCCTCATCCCGTGCAACTTTCTTAAAGCAGTCGTTTAATGACAGGTTGTGTCTTATAGAGTTCTGCCAGCCGGCTTTACTTTTCTTGTAAAAGGGAAAGTTGTCAGCCACGTACTGATAAATCTGACTGAGCGTCAGTTTCTTATCCTGCGCGTTCTGGATAGCCATCGCAATCAGCGCCGAGTACGAGTACGGCGGTCTGACCATCTTGAAAAGTTCTTGCTGACTTGATATGGAGAGCCAGCCCAAATCCGCGCTTCCAAAGCCGGTAGGAGGAGGGAGAAACTGCCGCTGGTTGGATCCAAATCCCGACTGGATATAAGAGCCTCCGTTTGGGCTTGAGAGGTACGGGGTGGAGGTGATGCCCGGGCTGTTCATCCACAGGTAAGGGTTGGTGCTCGGCGAGCTGTACTCGCCGAGCCCGTAGCTGGAGGGATGCGCAGGCGGCCTCTGGTGGTGGTGATGGTGGTGATGATGGTGCAGGTTCTGCTGGTACAT
GCT/C GAAGTTGGAGTCGCAGTACACGGTCATGTCCAGGATGTCCTGCTGCTGAAGGGGACTGGTCTGCTGGCTCGACGGCTGCTGCCCAAACGCGTTCATAATCCGCTCTCCCTCCAGAAACATGGAGTTTCTCCGATCTGACCTGCTGAGTGTGCTCGTCTCTGAGGGGTTTCTCAAGGAGAGTGTCCGGGTGCGCTTCAGGGGAGGGTTATTTAACCTGTCCGGGGCGCATGCAGTGAATGGACTCATGTTGACTACTCCTCCCACTGTCACACTTCTTCTCAATTAACTTCATCCAATATGCATCAATCTGGCGTCGAGATCATTCACGTGATAAGCTTGCCGAACAAAGACTGTTTAAGCGCTAAAAAGGGTGGACACGTCTAAAAAATGGAAGATAGTTACACTGTAAAAAAAATAAAAAATCTTAAAATAAGTTTATACGAAGTCTCACTTTTTTTGTTAAACAAGCTGTTCTAAAGCGATAGTTCACCCTCAAGTGT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| foxi1em1/em1 | Homozygous | Unknown | Fig. for (em1) from Phenotype Annotation (1994-2006) | 5 figures  from 3 publications | |
| foxi1em1/em1 | Homozygous | ♀+/- ♂+/- | 7 figures from 4 publications | 8 figures from 5 publications | |
| foxi1em1/+ (AB) | Heterozygous | Unknown | |||
| foxi1em1/em1 + MO1-dlx3b | Complex | Fig. 7 from Hans et al., 2004 | |||
| foxi1em1/em1; Df(Chr12:dlx3b, dlx4b)tud70/tud70 (AB) | Complex | Fig. 2 from Schwarzer et al., 2017 | 2 figures from Schwarzer et al., 2017 |
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Supplemental Information
- Genotyping protocol
- None
- Jin, S., Jiyun, O., Stellabotte, F., Choe, C.P. (2018) Foxi1 promotes late-stage pharyngeal pouch morphogenesis through ectodermal Wnt4a activation. Developmental Biology. 441(1):12-18
- Schwarzer, S., Spieß, S., Brand, M., Hans, S. (2017) Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biology Open. 6(9):1270-1278
- Swartz, M.E., Wells, M.B., Griffin, M., McCarthy, N., Lovely, C.B., McGurk, P., Rozacky, J., and Eberhart, J.K. (2014) A Screen of Zebrafish Mutants Identifies Ethanol-Sensitive Genetic Loci. Alcoholism, clinical and experimental research. 38(3):694-703
- Yao, D., Zhao, F., Wu, Y., Wang, J., Wei, D., Zhao, J., Zhu, Z., Liu, D. (2014) Dissecting the differentiation process of the pre-placodal ectoderm in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(10):1338-51
- Hans, S., Irmscher, A., and Brand, M. (2013) Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development (Cambridge, England). 140(9):1936-1945
- Hans, S., Christison, J., Liu, D., and Westerfield, M. (2007) Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Developmental Biology. 7(1):5
- Nechiporuk, A., Linbo, T., Poss, K.D., and Raible, D.W. (2007) Specification of epibranchial placodes in zebrafish. Development (Cambridge, England). 134(3):611-623
- Nechiporuk, A., Linbo, T., and Raible, D.W. (2005) Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish. Development (Cambridge, England). 132(16):3717-3730
- Hans, S., Liu, D., and Westerfield, M. (2004) Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development (Cambridge, England). 131(20):5091-5102
- Solomon, K.S., Kwak, S.J., and Fritz, A. (2004) Genetic interactions underlying otic placode induction and formation. Developmental Dynamics : an official publication of the American Association of Anatomists. 230(3):419-433
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