| ZFIN ID: ZDB-EXP-250102-6 |
Experiment Conditions Description: heat shock, chemical treatment by environment: alvocidib
| heat shock |
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| Name: | heat shock |
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| Synonyms: | |
| Definition: | Temperature shock condition in which fish are subjected for a short period of time to temperature higher than the controlled temperature. The standard controlled temperature (according to the zebrafish book) is 28.5 degrees C. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000166] |
| chemical treatment by environment: alvocidib |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | alvocidib |
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| Synonyms: | (-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one, alvocidib, alvocidibum, Flavopiridol, HMR 1274, HMR-1274, L 86-8275, L 868275, L-868275, L86-8275 |
| Definition: | A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation. |
| Ontology: | ChEBI [CHEBI:47344] ( EBI ) |
| Publication: | Ye et al., 2022 |
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