ZFIN ID: ZDB-EXP-240221-7
Experiment Conditions Description: chemical treatment by environment: biliatresone, chemical treatment by environment: N-acetyl-L-cysteine, chemical treatment by environment: 8-bromo-3',5'-cyclic GMP
chemical treatment by environment: biliatresone
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: biliatresone
Synonyms: 1-(4,6-dimethoxy-1,3-benzodioxol-5-yl)-2-(2-hydroxyphenyl)prop-2-en-1-one, 2-[2-(2-hydroxyphenyl)-3-oxoprop-1-en-3-yl]-1,3-dimethoxy-4,5-methylenedioxybenzene
Definition: A member of the class of benzodioxoles that is 1,3-benzodioxole which is substituted at positions 5 by a 2-(2-hydroxyphenyl)-3-oxoprop-1-en-3-yl group and at positions 4 and 6 by methoxy groups. A very rare type of isoflavonoid-related 1,2-diaryl-2-propenone found in Dysphania glomulifera (red crumbweed) and D. littoralis, the enone moiety is particularly reactive, undergoing ready Michael addition of water and methanol. Biliatresone has been found to cause extrahepatic biliary atresia (obliteration or discontinuity of the extrahepatic biliary system, resulting in obstruction to bile flow) in a zebrafish model.
Ontology: ChEBI [CHEBI:131631]  ( EBI )
chemical treatment by environment: N-acetyl-L-cysteine
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: N-acetyl-L-cysteine
Synonyms: (2R)-2-acetylamino-3-sulfanylpropanoic acid, (R)-2-acetylamino-3-mercaptopropanoic acid, (R)-mercapturic acid, acetilcisteina, Acetylcysteine, acetylcysteinum, L-acetylcysteine, L-alpha-acetamido-beta-mercaptopropionic acid, mercapturic acid, N-acetyl-L-(+)-cysteine, N-ACETYL-L-CYSTEINE, N-acetylcysteine, NAC
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Ontology: ChEBI [CHEBI:28939]  ( EBI )
chemical treatment by environment: 8-bromo-3',5'-cyclic GMP
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: 8-bromo-3',5'-cyclic GMP
Synonyms: 8-Br-cGMP, 8-Br-Cyclic GMP, 8-Bromo-cgmp, 8-Bromocyclic GMP, 8-Bromocyclic guanosine monophosphate, 8-bromoguanosine 3',5'-(hydrogen phosphate), 8-Bromoguanosine 3',5'-cyclic monophosphate, 8-Bromoguanosine 3',5'-monophosphate
Definition: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
Ontology: ChEBI [CHEBI:64108]  ( EBI )
Publication: Zhao et al., 2020