ZFIN ID: ZDB-EXP-240216-4
Experiment Conditions Description: chemical treatment by environment: CK-666
chemical treatment by environment: CK-666
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: CK-666
Synonyms: 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide, CK 666, CK-0944666, CK666
Definition: A member of the class of indoles that is 2-methyltryptamine in which a hydrogen attached to the primary amino group has been replaced by a 2-fluorobenzoyl group. It is a cell-permeable inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex which works by binding to Arp2/3 complex, stabilising the inactive state of the complex and preventing its movement into the active conformation.
Ontology: ChEBI [CHEBI:78843]  ( EBI )
Publication: Inaba et al., 2020