| ZFIN ID: ZDB-EXP-230907-7 |
Experiment Conditions Description: physical alteration: skeletal muscle, chemical treatment by environment: cenicriviroc, chemical treatment by environment: Recombinant Visfatin
| physical alteration: skeletal muscle |
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| Name: | physical alteration |
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| Synonyms: | |
| Definition: | Experimental condition in which an anatomical structure, cell, or organ has sustained targeted physical change, usually through the use of an instrument. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000229] |
| Name: | skeletal muscle |
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| Synonyms: | |
| Definition: | Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons. |
| Ontology: | Anatomy Ontology [ZFA:0005277] |
| chemical treatment by environment: cenicriviroc |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | cenicriviroc |
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| Synonyms: | (5E)-8-[4-(2-butoxyethoxy)phenyl]-1-(2-methylpropyl)-N-(4-{(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide, cenicriviroc, cenicrivirocum, CVC, TAK-652, TBR 652, TBR-652 |
| Definition: | A member of the class of benzazocines that is (5Z)-1,2,3,4-tetrahydro-1-benzazocine which is substituted by a 2-methylpropyl, N-{4-[(S)-(1-propyl-1H-imidazol-5-yl)methanesulfinyl]phenyl}carboxamide and 4-(2-butoxyethoxy)phenyl groups at positions 1, 5 and 8, respectively. It is a potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis (NASH). |
| Ontology: | ChEBI [CHEBI:149636] ( EBI ) |
| chemical treatment by environment: Recombinant Visfatin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | Recombinant Visfatin |
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| Synonyms: | NAmPRTase (nicotinamide phosphoribosyltransferase), Nampt, PBEF (Pre-B cell colony-enhancing factor) |
| Definition: | Recombinant Human Visfatin is a 52.6 kDa protein containing 466 amino acid residues (isoform 1). AA Sequence:MPPNTSKVYS YFECREKKTE NSKLRKVKYE ETVFYGLQYI LNKYLKGKVV TKEKIQEAKD VYKEHFQDDV FNEKGWNYIL EKYDGHLPIE IKAVPEGFVI PRGNVLFTVE NTDPECYWLT NWIETILVQS WYPITVATNS REQKKILAKY LLETSGNLDG LEYKLHDFGY RGVSSQETAG IGASAHLVNF KGTDTVAGLA LIKKYYGTKD PVPGYSVPAA EHSTITAWGK DHEKDAFEHI VTQFSSVPVS VVSDSYDIYN ACEKIWGEDL RHLIVSRSTQ APLIIRPDSG NPLDTVLKVL EILGKKFPVT ENSKGYKLLP PYLRVIQGDG VDINTLQEIV EGMKQKMWSI ENIAFGSGGG LLQKLTRDLL NCSFKCSYVV TNGLGINVFK DPVADPNKRS KKGRLSLHRT PAGNFVTLEE GKGDLEEYGQ DLLHTVFKNG KVTKSYSFDE IRKNAQLNIE LEAAHH |
| Ontology: | ChEBI [CHEBI:195368] ( EBI ) |
| Publication: | Ratnayake et al., 2021 |
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