| ZFIN ID: ZDB-EXP-230907-5 |
Experiment Conditions Description: physical alteration: skeletal muscle, chemical treatment by environment: cenicriviroc
| physical alteration: skeletal muscle |
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| Name: | physical alteration |
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| Synonyms: | |
| Definition: | Experimental condition in which an anatomical structure, cell, or organ has sustained targeted physical change, usually through the use of an instrument. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000229] |
| Name: | skeletal muscle |
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| Synonyms: | |
| Definition: | Muscle, composed of long cylindrical, multinucleated cells that attaches to the skeleton via tendons. |
| Ontology: | Anatomy Ontology [ZFA:0005277] |
| chemical treatment by environment: cenicriviroc |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | cenicriviroc |
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| Synonyms: | (5E)-8-[4-(2-butoxyethoxy)phenyl]-1-(2-methylpropyl)-N-(4-{(S)-[(1-propyl-1H-imidazol-5-yl)methyl]sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide, cenicriviroc, cenicrivirocum, CVC, TAK-652, TBR 652, TBR-652 |
| Definition: | A member of the class of benzazocines that is (5Z)-1,2,3,4-tetrahydro-1-benzazocine which is substituted by a 2-methylpropyl, N-{4-[(S)-(1-propyl-1H-imidazol-5-yl)methanesulfinyl]phenyl}carboxamide and 4-(2-butoxyethoxy)phenyl groups at positions 1, 5 and 8, respectively. It is a potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis (NASH). |
| Ontology: | ChEBI [CHEBI:149636] ( EBI ) |
| Publication: | Ratnayake et al., 2021 |
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