| ZFIN ID: ZDB-EXP-201005-1 |
Experiment Conditions Description: perforation: retina, chemical treatment by injection: sirolimus
| perforation: retina |
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| Name: | perforation |
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| Synonyms: | |
| Definition: | Experimental condition in which a hole or break in the membranes of an organ or structure of the body is created. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000178] |
| Name: | retina |
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| Synonyms: | retinas |
| Definition: | Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup. |
| Ontology: | Anatomy Ontology [ZFA:0000152] |
| chemical treatment by injection: sirolimus |
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| Name: | chemical treatment by injection |
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| Synonyms: | |
| Definition: | Chemical treatment in which the chemical is injected into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000237] |
| Name: | sirolimus |
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| Synonyms: | (-)-Rapamycin, (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tet, (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-ep, Antibiotic AY 22989, Rapamune, rapamycin, sirolimus, sirolimusum |
| Definition: | A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent. |
| Ontology: | ChEBI [CHEBI:9168] ( EBI ) |
| Publication: | Zhang et al., 2019 |
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