| ZFIN ID: ZDB-EXP-200521-12 |
Experiment Conditions Description: cold shock, chemical treatment by environment: thapsigargin
| cold shock |
|---|
| Name: | cold shock |
|---|---|
| Synonyms: | |
| Definition: | Temperature shock condition in which fish are subjected for a short period of time to temperature lower than the controlled temperature. The standard controlled temperature (according to the zebrafish book) is 28.5 degrees C. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000165] |
| chemical treatment by environment: thapsigargin |
|---|
| Name: | chemical treatment by environment |
|---|---|
| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | thapsigargin |
|---|---|
| Synonyms: | (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester, Tg, Thapsigargin, thapsigargine |
| Definition: | An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. |
| Ontology: | ChEBI [CHEBI:9516] ( EBI ) |
| Publication: | Chen et al., 2019 |
|---|