| ZFIN ID: ZDB-EXP-171017-10 |
Experiment Conditions Description: chemical treatment by environment: aphidicolin, chemical treatment by environment: 6-bromoindirubin-3'-oxime, chemical treatment by environment: hydroxyurea
| chemical treatment by environment: aphidicolin |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | aphidicolin |
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| Synonyms: | (3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol, Aphidicolin, aphidocolin |
| Definition: | A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. |
| Ontology: | ChEBI [CHEBI:2766] ( EBI ) |
| chemical treatment by environment: 6-bromoindirubin-3'-oxime |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | 6-bromoindirubin-3'-oxime |
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| Synonyms: | (2Z,3E)-6'-bromo-2,3'-biindole-2',3(1H,1'H)-dione 3-oxime, (2Z,3E)-6-Bromoindirubin-3'-oxime, (3Z)-6-bromo-3-[(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one, 6-BIO |
| Definition: | A member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime. |
| Ontology: | ChEBI [CHEBI:86290] ( EBI ) |
| chemical treatment by environment: hydroxyurea |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | hydroxyurea |
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| Synonyms: | carbamohydroxamic acid, carbamohydroximic acid, carbamoyl oxime, carbamyl hydroxamate, hidroxicarbamida, hydrea, Hydroxycarbamid, Hydroxycarbamide, hydroxycarbamidum, Hydroxyharnstoff, Hydroxyurea, N-carbamoylhydroxylamine, N-hydroxyurea, oxyurea |
| Definition: | A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. |
| Ontology: | ChEBI [CHEBI:44423] ( EBI ) |
| Publication: | Naylor et al., 2017 |
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