| ZFIN ID: ZDB-EXP-151210-4 |
Experiment Conditions Description: resection: bulbus arteriosus, resection: cardiac ventricle, organ culture: heart, chemical treatment: metronidazole
| resection: bulbus arteriosus |
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| Name: | resection |
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| Synonyms: | |
| Definition: | Surgical manipulation in which a particular organ, appendage, or part of an organism is removed. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000171] |
| Name: | bulbus arteriosus |
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| Synonyms: | cardiac outflow tract, outflow tract, truncus |
| Definition: | Multi-tissue structure that consists of three layers and through which the blood exits the heart. The bulbus arteriosus is a pear shaped chamber that functions as a capacitor, maintaining continuous blood flow into the gill arches. |
| Ontology: | Anatomy Ontology [ZFA:0000173] |
| resection: cardiac ventricle |
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| Name: | resection |
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| Synonyms: | |
| Definition: | Surgical manipulation in which a particular organ, appendage, or part of an organism is removed. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000171] |
| Name: | cardiac ventricle |
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| Synonyms: | ventricle |
| Definition: | Cavitated compound organ that receives blood flow from the atrium and delivers blood to the body via the aorta. Valves are present to direct flow. There are only two chambers present in the fish heart. |
| Ontology: | Anatomy Ontology [ZFA:0000009] |
| organ culture: heart |
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| Name: | organ culture |
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| Synonyms: | |
| Definition: | In vitro culture condition in which an organ is dissected/isolated/collected from the fish and placed in culture. The analysis of the experiment is done on this organ in culture. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000144] |
| Name: | heart |
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| Synonyms: | |
| Definition: | Blood pumping organ composed of four components: sinus venosus, atrium, cardiac ventricle and bulbus arteriosus. |
| Ontology: | Anatomy Ontology [ZFA:0000114] |
| chemical treatment: metronidazole |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | metronidazole |
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| Synonyms: | 1-(2-hydroxy-1-ethyl)-2-methyl-5-nitroimidazole, 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-ethylol)-2-methyl-5-nitro-3-azapyrrole, 1-(beta-hydroxyethyl)-2-methyl-5-nitroimidazole, 1-(beta-oxyethyl)-2-methyl-5-nitroimidazole, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol, 2-methyl-1-(2-hydroxyethyl)-5-nitroimidazole, 2-methyl-3-(2-hydroxyethyl)-4-nitroimidazole, 2-methyl-5-nitroimidazole-1-ethanol, metronidazol, metronidazole, metronidazolum |
| Definition: | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. |
| Ontology: | ChEBI [CHEBI:6909] ( EBI ) |
| Publication: | Wang et al., 2015 |
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