| ZFIN ID: ZDB-EXP-131118-13 |
Experiment Conditions Description: chemical treatment: aphidicolin, chemical treatment: hydroxyurea
| chemical treatment: aphidicolin |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | aphidicolin |
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| Synonyms: | (3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol, Aphidicolin, aphidocolin |
| Definition: | A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. |
| Ontology: | ChEBI [CHEBI:2766] ( EBI ) |
| chemical treatment: hydroxyurea |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | hydroxyurea |
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| Synonyms: | carbamohydroxamic acid, carbamohydroximic acid, carbamoyl oxime, carbamyl hydroxamate, hidroxicarbamida, hydrea, Hydroxycarbamid, hydroxycarbamide, hydroxycarbamidum, Hydroxyharnstoff, Hydroxyurea, N-carbamoylhydroxylamine, N-hydroxyurea, oxyurea |
| Definition: | A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease. |
| Ontology: | ChEBI [CHEBI:44423] ( EBI ) |
| Publication: | Nicoli et al., 2012 |
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