| ZFIN ID: ZDB-EXP-131002-7 |
Experiment Conditions Description: cancer xenotransplantation, chemical treatment: vatalanib
| cancer xenotransplantation |
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| Name: | cancer xenotransplantation |
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| Synonyms: | |
| Definition: | Xenotransplantation condition in which cancer cells are injected or grafted into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000236] |
| chemical treatment: vatalanib |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | vatalanib |
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| Synonyms: | CGP 79787, CGP-79787, CGP79787, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine, N-(p-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine, PTK 787, PTK-787, PTK/ZK, PTK787, vatalanib, ZK-232934 |
| Definition: | A member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit. |
| Ontology: | ChEBI [CHEBI:90620] ( EBI ) |
| Publication: | Hollenbach et al., 2013 |
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