| ZFIN ID: ZDB-EXP-060821-3 |
Experiment Conditions Description: ablation: cerebellum, chemical treatment: SU5402
| ablation: cerebellum |
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| Name: | ablation |
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| Synonyms: | |
| Definition: | Targeted destruction of an anatomical structure. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000168] |
| Name: | cerebellum |
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| Synonyms: | |
| Definition: | Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata and thus these are not distinguished here. |
| Ontology: | Anatomy Ontology [ZFA:0000100] |
| chemical treatment: SU5402 |
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| Name: | chemical treatment |
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| Synonyms: | |
| Definition: | Experimental condition in which the fish is treated with a chemical substance. This treatment could be administered by adding the chemical substance to the tank water, injections, or by consumption. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000111] |
| Name: | SU5402 |
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| Synonyms: | 3-[3-(2-carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone, 3-{4-methyl-2-[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid, 3-{[3-(2-carboxyethyl)-4-methylpyrrol-2-yl]methylene}-2-indolinone, SU 5402, SU-5402 |
| Definition: | An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 3-(2-carboxyethyl)-4-methyl-1H-pyrrol-2-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1. |
| Ontology: | ChEBI [CHEBI:63449] ( EBI ) |
| Publication: | Koster et al., 2006 |
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