PUBLICATION
Molecular mechanisms of vertebrate left–right development
- Authors
- Ramsdell, A.F. and Yost, H.J.
- ID
- ZDB-PUB-990604-7
- Date
- 1998
- Source
- Trends in genetics : TIG 14(11): 459-465 (Review)
- Registered Authors
- Ramsdell, Ann F., Yost, H. Joseph
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning/genetics*
- Embryo, Nonmammalian
- Functional Laterality/physiology*
- Gene Expression Regulation, Developmental*
- Humans
- Mesoderm
- Vertebrates/physiology*
- Xenopus/embryology
- PubMed
- 9825674 Full text @ Trends Genet.
Citation
Ramsdell, A.F. and Yost, H.J. (1998) Molecular mechanisms of vertebrate left–right development. Trends in genetics : TIG. 14(11):459-465.
Abstract
Patterning of all tissues and organs in the vertebrate embryo occurs along the dorsoventral (DV), anteroposterior (AP), and left-right (LR) body axes. Whereas significant progress has been made in identifying the processes underlying DV and AP patterning, relatively little is known about mechanisms guiding LR development. The significant incidence of human disease conditions associated with LR laterality defects, particularly those of the cardiovascular system, underscores the importance of understanding how LR asymmetries become established in the embryo. The focus of this review is on recently identified genes that are involved in generation of vertebrate LR asymmetry, and the proposed cellular and molecular mechanisms by which they might function in initiation, propagation and interpretation of LR patterning information.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping