PUBLICATION
A zebrafish homolog of the serum response factor gene is highly expressed in differentiating embryonic myocytes
- Authors
- Vogel, A.M. and Gerster, T.
- ID
- ZDB-PUB-990506-6
- Date
- 1999
- Source
- Mechanisms of Development 81(1-2): 217-221 (Journal)
- Registered Authors
- Gerster, Thomas, Vogel, Andreas M.
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- DNA-Binding Proteins/analysis
- DNA-Binding Proteins/genetics*
- Gene Library
- Molecular Sequence Data
- Muscle, Skeletal/embryology*
- Muscle, Skeletal/metabolism
- Nuclear Proteins/analysis
- Nuclear Proteins/genetics*
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Homology, Amino Acid
- Serum Response Factor
- Zebrafish/genetics*
- PubMed
- 10330504 Full text @ Mech. Dev.
Citation
Vogel, A.M. and Gerster, T. (1999) A zebrafish homolog of the serum response factor gene is highly expressed in differentiating embryonic myocytes. Mechanisms of Development. 81(1-2):217-221.
Abstract
Serum response factor (SRF) was identified as an activity binding upon serum stimulation of HeLa cells to a motif known as the serum response element in the c-fos promoter. This element is also found in the regulatory regions of many muscle-specific genes. We have characterized srf expression during early zebrafish embryogenesis. In addition to low-level expression in many or even all cells, elevated levels of srf RNA and protein are transiently expressed in skeletal muscle lineages during their differentiation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping