PUBLICATION
The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER
- Authors
- Cousin, X., Hotelier, T., Giles, K., Lievin, P., Toutant, J.P., and Chatonnet, A.
- ID
- ZDB-PUB-970418-30
- Date
- 1997
- Source
- Nucleic acids research 25: 143-146 (Journal)
- Registered Authors
- Chatonnet, Arnaud, Cousin, Xavier, Toutant, Jean-Pierre
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Cholinesterases/genetics*
- Databases, Factual*
- Genes/genetics
- Humans
- Lipase/genetics*
- Molecular Sequence Data
- Software
- PubMed
- 9016525 Full text @ Nucleic Acids Res.
Citation
Cousin, X., Hotelier, T., Giles, K., Lievin, P., Toutant, J.P., and Chatonnet, A. (1997) The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER. Nucleic acids research. 25:143-146.
Abstract
ESTHER (for esterases, [alpha] / [beta] hydrolase enzyme and relatives) is a database of sequences phylogenetically related to cholinesterases. These sequences define a homogeneous group of enzymes (carboxylesterases,lipases and hormone-sensitive lipases) sharing a similar structure of a central [beta] -sheet surrounded by [alpha] -helices. Among these proteins a wide range of functions can be found (hydrolases, adhesion molecules, hormone precursors). The purpose of ESTHER is to help comparison of structures and functions of members of the family. Since the last release, new features have been added to the server. A BLAST comparison tool allows sequence homology searches within the database sequences. New sections are available: kinetics and inhibitors of cholinesterases, fasciculin-acetylcholinesterase interaction and a gene structure review. The mutation analysis compilation has been improved with three-dimensional images. A mailing list has been created.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping