PUBLICATION
Transfer from ciliate to zebrafish: Unveiling mechanisms and combined effects of microplastics and heavy metals
- Authors
- Zhang, Y., Wang, C., Jia, R., Long, H., Zhou, J., Sun, G., Wang, Y., Zhang, Z., Rong, X., Jiang, Y.
- ID
- ZDB-PUB-240828-13
- Date
- 2024
- Source
- Journal of hazardous materials 479: 135645135645 (Journal)
- Registered Authors
- Rong, Xiaozhi, Wang, Caixia, Zhou, Jianfeng
- Keywords
- Composite pollutants, Microbial loop, Top predator, Toxicological mechanisms, Trophic transfer
- MeSH Terms
-
- Animals
- Apoptosis/drug effects
- Bioaccumulation
- Cadmium*/toxicity
- DNA Damage/drug effects
- Food Chain
- Gastrointestinal Microbiome/drug effects
- Metals, Heavy/toxicity
- Microplastics*/toxicity
- Paramecium caudatum/drug effects
- Water Pollutants, Chemical*/toxicity
- Zebrafish*
- PubMed
- 39191009 Full text @ J. Hazard. Mater.
Citation
Zhang, Y., Wang, C., Jia, R., Long, H., Zhou, J., Sun, G., Wang, Y., Zhang, Z., Rong, X., Jiang, Y. (2024) Transfer from ciliate to zebrafish: Unveiling mechanisms and combined effects of microplastics and heavy metals. Journal of hazardous materials. 479:135645135645.
Abstract
The impacts and toxicological mechanisms of microplastics (MPs) or heavy metals on aquatic ecosystems have been the subject of extensive research and initial understanding. However, the combined toxicity of co-pollutants on organisms and cumulative toxic effects along the food chain are still underexplored. In this study, the ciliate protozoan Paramecium caudatum and zebrafish Danio rerio were used to represent the microbial loop and the higher trophic level, respectively, to illustrate the progressive exposure of MPs and cadmium (Cd2+). The findings indicate that MPs (ca. 1 ×105 items/L) containing with Cd2+ (below 0.1 µg/L) could permeate the bodies of zebrafish through trophic levels after primary ingestion by ciliates. This could cause adverse effects on zebrafish, including alterations in bioindicators (total sugar, triglycerides, lactate, and glycogen) associated with metabolism, delayed hepatic development, disruption of intestinal microbiota, DNA damage, inflammatory responses, and abnormal cellular apoptosis. In addition, the potential risks associated with the transfer of composite pollutants through the microbial loop into traditional food chain were examined, offering novel insights on the evaluation of the ecological risks associated with MPs. As observed, understanding the bioaccumulation and toxic effects of combined pollutants in zebrafish holds crucial implications for food safety and human health.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping