PUBLICATION
Special Distribution of Nanoplastics in the Central Nervous System of Zebrafish during Early Development
- Authors
- Hong, W., Zhang, M., Wang, F., Li, Z., Li, Z., Wei, J., Song, M., Qian, Y., Pang, S., Wang, L., Zhao, H., Cao, M., Shi, J., Liang, Y.
- ID
- ZDB-PUB-240626-7
- Date
- 2024
- Source
- ACS nano 18(27): 17509-17520 (Journal)
- Registered Authors
- Cao, Mengxi, Liang, Yong, Pang, Shaochen, Wang, Ling
- Keywords
- central nervous system, maternal gamete exposure, neurotoxicity, polystyrene nanoplastics, special distribution
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Central Nervous System*/drug effects
- Central Nervous System*/metabolism
- Microplastics/toxicity
- Nanoparticles/chemistry
- Nanoparticles/metabolism
- Polystyrenes*/chemistry
- Zebrafish*/embryology
- PubMed
- 38918939 Full text @ ACS Nano
Citation
Hong, W., Zhang, M., Wang, F., Li, Z., Li, Z., Wei, J., Song, M., Qian, Y., Pang, S., Wang, L., Zhao, H., Cao, M., Shi, J., Liang, Y. (2024) Special Distribution of Nanoplastics in the Central Nervous System of Zebrafish during Early Development. ACS nano. 18(27):17509-17520.
Abstract
There is growing concern about the distribution of nanoplastics (NPs) in the central nervous system (CNS), whereas intrusion is poorly understood. In this study, fluorescent-labeled polystyrene NPs (PS-NPs) were microinjected into different areas of zebrafish embryo to mimic different routes of exposure. PS-NPs were observed in the brain, eyes, and spinal cord through gametal exposure. It indicated that maternally derived PS-NPs were specially distributed in the CNS of zebrafish during early development. Importantly, these NPs were stranded in the CNS but not transferred to other organs during development. Furthermore, using neuron GFP-labeled transgenic zebrafish, colocalization between NPs and the neuron cells revealed that NPs were mostly enriched in the CNS surrounded but not the neurons. Even so, the intrusion of NPs into the CNS induced the significant upregulation of some neurotransmitter receptors, leading to an inhibited effect on the movement of zebrafish larvae. This work provides insights into understanding the intrusion and distribution of NPs in the CNS and the subsequent potential adverse effects.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping