PUBLICATION
Effect of short-term exposure to the strobilurin fungicide dimoxystrobin: Morphofunctional, behavioural and mitochondrial alterations in Danio rerio embryos and larvae
- Authors
- Ahmed, A.I.M., Macirella, R., Talarico, F., Muoio, M.F., Mezzasalma, M., Tronci, V., Lal, P., Gharbi, N., Brunelli, E.
- ID
- ZDB-PUB-240529-7
- Date
- 2024
- Source
- Ecotoxicology and environmental safety 279: 116493116493 (Journal)
- Registered Authors
- Lal, Pradeep
- Keywords
- Development toxicity, Dimoxystrobin, Locomotor activity, Mitochondrial function, Strobilurins, Swim bladder inflation
- MeSH Terms
-
- Air Sacs/drug effects
- Animals
- Behavior, Animal/drug effects
- Embryo, Nonmammalian*/drug effects
- Fungicides, Industrial*/toxicity
- Larva*/drug effects
- Mitochondria*/drug effects
- Strobilurins*/toxicity
- Swimming
- Water Pollutants, Chemical*/toxicity
- Zebrafish*
- PubMed
- 38805825 Full text @ Ecotoxicol. Environ. Saf.
Citation
Ahmed, A.I.M., Macirella, R., Talarico, F., Muoio, M.F., Mezzasalma, M., Tronci, V., Lal, P., Gharbi, N., Brunelli, E. (2024) Effect of short-term exposure to the strobilurin fungicide dimoxystrobin: Morphofunctional, behavioural and mitochondrial alterations in Danio rerio embryos and larvae. Ecotoxicology and environmental safety. 279:116493116493.
Abstract
Strobilurins, among the most used fungicides worldwide, are considered non-toxic to mammals and birds, but there is growing evidence that these compounds are highly toxic to aquatic species. Dimoxystrobin has been included in the 3rd Watch List of the European Commission, and it has been classified as very toxic to aquatic life. However, previous studies focused on acute toxicity and only two reports are available on its impact on fish, and none on its effects during the early life stages. Here, we evaluated for the first time the effects induced on zebrafish embryos and larvae by two dimoxystrobin sublethal concentrations (6.56 and 13.13 μg/L) falling in the range of predicted environmental concentrations. We demonstrated that short-term exposure to dimoxystrobin may exert adverse effects on multiple targets, inducing severe morphological alterations. Moreover, we showed enhanced mRNA levels of genes related to the mitochondrial respiratory chain and ATP production. Impairment of the swim bladder inflation has also been recorded, which may be related to the observed swimming performance alterations.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping