PUBLICATION
Mob4 is required for neurodevelopment in zebrafish
- Authors
- Florindo, C., Mimoso, J.M., Palma, S.L., Gonçalves, C., Silvestre, D., Campinho, M., Tavares, Á.A.
- ID
- ZDB-PUB-230315-36
- Date
- 2023
- Source
- microPublication. Biology 2023: (Journal)
- Registered Authors
- Campinho, Marco António
- Keywords
- none
- MeSH Terms
- none
- PubMed
- 36915897 Full text @ MicroPubl Biol
Citation
Florindo, C., Mimoso, J.M., Palma, S.L., Gonçalves, C., Silvestre, D., Campinho, M., Tavares, Á.A. (2023) Mob4 is required for neurodevelopment in zebrafish. microPublication. Biology. 2023:.
Abstract
Mob4 is an essential evolutionary conserved protein shown to play roles in cell division and neural development. Mob4 is a core component of the macromolecular STRIPAK complex involved in various critical cellular processes, from cell division to signal transduction pathways. However, Mob4 remains relatively poorly understood. Although the consequences of eliminating Mob4 function in Drosophila are described, its function in vertebrate development remains largely unknown. Here we show that knockdown and knockout of Mob4 during zebrafish embryogenesis limits neuronal cell divisions but has little effect on apoptosis, thus arguing a role for mob4 in neurodevelopment.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping