PUBLICATION
Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis
- Authors
- Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L.
- ID
- ZDB-PUB-220210-5
- Date
- 2022
- Source
- eLIFE 11: (Journal)
- Registered Authors
- Martin, Benjamin, Waxman, Joshua
- Keywords
- cell biology, developmental biology, zebrafish
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Embryo, Nonmammalian/blood supply*
- Embryonic Development/physiology*
- Gene Expression Regulation, Developmental/drug effects
- Neovascularization, Physiologic/physiology*
- Retinoids/pharmacology
- Somites/physiology*
- Tretinoin/metabolism
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- p-Aminoazobenzene/analogs & derivatives
- p-Aminoazobenzene/pharmacology
- PubMed
- 35137687 Full text @ Elife
Citation
Paulissen, E., Palmisano, N.J., Waxman, J., Martin, B.L. (2022) Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLIFE. 11:.
Abstract
Angioblasts that form the major axial blood vessels of the dorsal aorta and cardinal vein migrate towards the embryonic midline from distant lateral positions. Little is known about what controls the precise timing of angioblast migration and their final destination at the midline. Using zebrafish, we found that midline angioblast migration requires neighboring tissue rearrangements generated by somite morphogenesis. The somitic shape changes cause the adjacent notochord to separate from the underlying endoderm, creating a ventral midline cavity that provides a physical space for the angioblasts to migrate into. The anterior to posterior progression of midline angioblast migration is facilitated by retinoic acid induced anterior to posterior somite maturation and the subsequent progressive opening of the ventral midline cavity. Our work demonstrates a critical role for somite morphogenesis in organizing surrounding tissues to facilitate notochord positioning and angioblast migration, which is ultimately responsible for creating a functional cardiovascular system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping