PUBLICATION
An ancient adenosine receptor gains olfactory function in bony vertebrates
- Authors
- Kowatschew, D., Korsching, S.I.
- ID
- ZDB-PUB-210910-7
- Date
- 2021
- Source
- Genome biology and evolution 13(9): (Journal)
- Registered Authors
- Korsching, Sigrun
- Keywords
- adenosine receptor, lamprey, olfaction
- MeSH Terms
-
- Animals
- Olfactory Receptor Neurons*/physiology
- Phylogeny
- Receptors, Odorant*/genetics
- Receptors, Purinergic P1/genetics
- Zebrafish/genetics
- PubMed
- 34499158 Full text @ Genome Biol. Evol.
Citation
Kowatschew, D., Korsching, S.I. (2021) An ancient adenosine receptor gains olfactory function in bony vertebrates. Genome biology and evolution. 13(9).
Abstract
Nucleotides are an important class of odorants for aquatic vertebrates such as frogs and fishes, but also have manifold signalling roles in other cellular processes. Recently, an adenosine receptor believed to belong to the adora2 clade has been identified as an olfactory receptor in zebrafish. Here we set out to elucidate the evolutionary history of both this gene and its olfactory function. We have performed a thorough phylogenetic study in vertebrates, chordates and their sister group, ambulacraria, and show that the origin of the zebrafish olfactory receptor gene can be traced back to the most recent common ancestor of all three groups as a segregate sister clade (adorb) to the adora gene family. Eel, carp, and clawed frog all express adorb in a sparse and distributed pattern within their olfactory epithelium very similar to the pattern observed for zebrafish, i.e. consistent with a function as olfactory receptor. In sharp contrast, lamprey adorb-expressing cells are absent from the sensory region of the lamprey nose, but form a contiguous domain directly adjacent to the sensory region. Double-labeling experiments confirmed the expression of lamprey adorb in nonneuronal cells and are consistent with an expression in neuronal progenitor cells. Thus, adorb may have undergone a switch of function in the jawed lineage of vertebrates towards a role as olfactory receptor.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping