PUBLICATION
Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding
- Authors
- Xu, J., Casanave, R., Guo, S.
- ID
- ZDB-PUB-210705-3
- Date
- 2021
- Source
- Learning & memory (Cold Spring Harbor, N.Y.) 28: 228-238 (Journal)
- Registered Authors
- Guo, Su
- Keywords
- none
- MeSH Terms
-
- Animals
- Avoidance Learning/physiology*
- Behavior, Animal/physiology*
- Habituation, Psychophysiologic/physiology*
- Larva/physiology*
- Visual Perception/physiology*
- Zebrafish/physiology*
- PubMed
- 34131054 Full text @ Learn. Mem.
Citation
Xu, J., Casanave, R., Guo, S. (2021) Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding. Learning & memory (Cold Spring Harbor, N.Y.). 28:228-238.
Abstract
Balancing exploration and anti-predation are fundamental to the fitness and survival of all animal species from early life stages. How these basic survival instincts drive learning remains poorly understood. Here, using a light/dark preference paradigm with well-controlled luminance history and constant visual surrounding in larval zebrafish, we analyzed intra- and intertrial dynamics for two behavioral components, dark avoidance and center avoidance. We uncover that larval zebrafish display short-term learning of dark avoidance with initial sensitization followed by habituation; they also exhibit long-term learning that is sensitive to trial interval length. We further show that such stereotyped learning patterns is stimulus-specific, as they are not observed for center avoidance. Finally, we demonstrate at individual levels that long-term learning is under homeostatic control. Together, our work has established a novel paradigm to understand learning, uncovered sequential sensitization and habituation, and demonstrated stimulus specificity, individuality, as well as dynamicity in learning.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping