PUBLICATION
PARP inhibition suppresses topoisomerase 1 poisoning induced Caspase-3 dependent cell death in zebrafish embryos
- Authors
- Tsikarishvili, S., Karapetian, M., Kulikova, N., Zaalishvili, G.
- ID
- ZDB-PUB-210312-17
- Date
- 2021
- Source
- Biochemical and Biophysical Research Communications 550: 166-170 (Journal)
- Registered Authors
- Keywords
- Caspase-3, Olaparib, PARP-1, Rubitecan, Zebrafish embryo
- MeSH Terms
-
- Animals
- Apoptosis/drug effects*
- Camptothecin/analogs & derivatives
- Camptothecin/pharmacology
- Caspase 3/metabolism*
- DNA Topoisomerases, Type I/metabolism*
- Drug Synergism
- Phthalazines/pharmacology
- Piperazines/pharmacology
- Poly (ADP-Ribose) Polymerase-1/analysis
- Poly (ADP-Ribose) Polymerase-1/chemistry
- Poly (ADP-Ribose) Polymerase-1/metabolism*
- Poly(ADP-ribose) Polymerase Inhibitors/pharmacology*
- Topoisomerase I Inhibitors/pharmacology*
- Zebrafish/embryology*
- PubMed
- 33706100 Full text @ Biochem. Biophys. Res. Commun.
Citation
Tsikarishvili, S., Karapetian, M., Kulikova, N., Zaalishvili, G. (2021) PARP inhibition suppresses topoisomerase 1 poisoning induced Caspase-3 dependent cell death in zebrafish embryos. Biochemical and Biophysical Research Communications. 550:166-170.
Abstract
In the present study the role of poly(ADP)ribosylation on rubitecan induced caspase dependent cell death was evaluated. We show that Top1 poisoning by rubitecan induces caspase mediated apoptosis which was reduced by PARP inhibitor olaparib in zebrafish embryo. Collectively our data introduces zebrafish as a valuable model for PARP related biomedical research.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping