PUBLICATION
Stay hydrated: basolateral fluids shaping tissues
- Authors
- Schliffka, M.F., Maître, J.L.
- ID
- ZDB-PUB-190826-21
- Date
- 2019
- Source
- Current opinion in genetics & development 57: 70-77 (Other)
- Registered Authors
- Maître, Jean-Léon
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Water/cytology
- Body Water/metabolism
- Embryonic Development/genetics*
- Extracellular Fluid/cytology
- Extracellular Fluid/metabolism*
- Mice
- Morphogenesis/genetics*
- Zebrafish/genetics
- Zebrafish/growth & development
- PubMed
- 31445440 Full text @ Curr. Opin. Genet. Dev.
Citation
Schliffka, M.F., Maître, J.L. (2019) Stay hydrated: basolateral fluids shaping tissues. Current opinion in genetics & development. 57:70-77.
Abstract
During development, embryos perform a mesmerizing choreography, which is crucial for the correct shaping, positioning and function of all organs. The cellular properties powering animal morphogenesis have been the focus of much attention. In contrast, much less consideration has been given to the invisible engine constituted by the intercellular fluid. Cells are immersed in fluid, of which the composition and physical properties have a considerable impact on development. In this review, we revisit recent studies from the perspective of the fluid, focusing on basolateral fluid compartments and taking the early mouse and zebrafish embryos as models. These examples illustrate how the hydration levels of tissues are spatio-temporally controlled and influence embryonic development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping