PUBLICATION
A frameshift mutation in the PHD Finger Protein 21A repressor of transcription phf21aa
- Authors
- Mishoe, L.N., and DeLaurier, A.
- ID
- ZDB-PUB-190605-16
- Date
- 2019
- Source
- ZebraShare : (Unpublished)
- Registered Authors
- DeLaurier, April
- Keywords
- none
- MeSH Terms
- none
- PubMed
- none
Citation
Mishoe, L.N., and DeLaurier, A. (2019) A frameshift mutation in the PHD Finger Protein 21A repressor of transcription phf21aa. ZebraShare. .
Abstract
CRISPR-Cas9 mutagenesis was used to induce a mutation in exon 6 of zebrafish phf21aa. A 7 bp deletion was detected, producing extensive missense and a premature stop codon which is predicted to cause an aberrant and truncated protein. Homozygous mutants have normal external appearance although a mild rotation of the ceratohyal cartilage was detected at 7 dpf. Otherwise, the craniofacial skeleton is normal in mutants. Mutants are viable as adults.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping