PUBLICATION
Ca 2+ activity signatures of myelin sheath formation and growth in vivo
- Authors
- Baraban, M., Koudelka, S., Lyons, D.A.
- ID
- ZDB-PUB-190510-19
- Date
- 2018
- Source
- Nature Neuroscience 21: 19-23 (Other)
- Registered Authors
- Baraban, Marion, Lyons, David A.
- Keywords
- none
- MeSH Terms
-
- Acrylates/pharmacology
- Animals
- Animals, Genetically Modified
- Axons/physiology*
- Calcium/metabolism*
- Calpain/antagonists & inhibitors
- Larva
- Luminescent Proteins/genetics
- Luminescent Proteins/metabolism
- Myelin Sheath/drug effects
- Myelin Sheath/metabolism*
- Oligodendroglia/drug effects
- Oligodendroglia/physiology*
- RNA, Messenger/metabolism
- SOXE Transcription Factors/genetics
- SOXE Transcription Factors/metabolism
- Spinal Cord/physiology*
- Time Factors
- Time-Lapse Imaging
- Zebrafish
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 29230058 Full text @ Nat. Neurosci.
Citation
Baraban, M., Koudelka, S., Lyons, D.A. (2018) Ca 2+ activity signatures of myelin sheath formation and growth in vivo. Nature Neuroscience. 21:19-23.
Abstract
During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.
Genes / Markers
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Mutations / Transgenics
Human Disease / Model
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