PUBLICATION
A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa
- Authors
- Tu, Y.B., Xiao, T., Gong, G.Y., Bian, Y.Q., Li, Y.F.
- ID
- ZDB-PUB-190115-1
- Date
- 2019
- Source
- Natural Product Research 34(7): 981-987 (Journal)
- Registered Authors
- Xiao, Tong
- Keywords
- Millettia pachycarpa, anti-inflammatory activity, cytotoxicity, isoflavone
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents/isolation & purification*
- Anti-Inflammatory Agents/pharmacology
- Humans
- Isoflavones/chemistry
- Isoflavones/isolation & purification*
- Isoflavones/pharmacology
- Lipopolysaccharides
- Macrophages/drug effects
- Mice
- Millettia/chemistry*
- Nitric Oxide/biosynthesis
- RAW 264.7 Cells
- Seeds/chemistry*
- Zebrafish
- PubMed
- 30636441 Full text @ Nat. Prod. Res.
Citation
Tu, Y.B., Xiao, T., Gong, G.Y., Bian, Y.Q., Li, Y.F. (2019) A new isoflavone with anti-inflammatory effect from the seeds of Millettia pachycarpa. Natural Product Research. 34(7):981-987.
Abstract
A new isoflavone, milletenol A (1), along with four known flavonoids (2-5) were isolated from the seeds of Millettia pachycarpa. The structure of 1 was established by extensive spectroscopic methods while known compounds were identified by comparisons with literature data. Compound 1 and 2 showed significant anti-inflammatory activities against nitric oxide production in LPS-induced RAW264.7 macrophages. The state of CuSO4-stimulated inflammation was effectively alleviated by compound 1 in zebrafish. However, no significant cytotoxicity against human breast cancer cells was observed among all isolates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping