PUBLICATION

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

Authors
Nakayama, H., Shimada, Y., Zang, L., Terasawa, M., Nishiura, K., Matsuda, K., Toombs, C., Langdon, C., Nishimura, N.
ID
ZDB-PUB-181004-2
Date
2018
Source
Nutrients   10(10): (Journal)
Registered Authors
Keywords
adipogenesis, animal model, comparative genomics, metabolic syndrome
MeSH Terms
  • Adiposity/drug effects
  • Animals
  • Anti-Obesity Agents/administration & dosage*
  • Dietary Supplements
  • Female
  • Functional Food
  • Intra-Abdominal Fat/metabolism
  • Liver/metabolism
  • Male
  • Mice
  • Obesity/diet therapy*
  • Obesity/etiology
  • PPAR alpha/drug effects
  • PPAR gamma/drug effects
  • Phytotherapy/methods*
  • Powders/administration & dosage*
  • Seaweed/chemistry*
  • Zebrafish
PubMed
30279329 Full text @ Nutrients
Abstract
(1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping