PUBLICATION
Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models
- Authors
- Nakayama, H., Shimada, Y., Zang, L., Terasawa, M., Nishiura, K., Matsuda, K., Toombs, C., Langdon, C., Nishimura, N.
- ID
- ZDB-PUB-181004-2
- Date
- 2018
- Source
- Nutrients 10(10): (Journal)
- Registered Authors
- Keywords
- adipogenesis, animal model, comparative genomics, metabolic syndrome
- MeSH Terms
-
- Adiposity/drug effects
- Animals
- Anti-Obesity Agents/administration & dosage*
- Dietary Supplements
- Female
- Functional Food
- Intra-Abdominal Fat/metabolism
- Liver/metabolism
- Male
- Mice
- Obesity/diet therapy*
- Obesity/etiology
- PPAR alpha/drug effects
- PPAR gamma/drug effects
- Phytotherapy/methods*
- Powders/administration & dosage*
- Seaweed/chemistry*
- Zebrafish
- PubMed
- 30279329 Full text @ Nutrients
Citation
Nakayama, H., Shimada, Y., Zang, L., Terasawa, M., Nishiura, K., Matsuda, K., Toombs, C., Langdon, C., Nishimura, N. (2018) Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models. Nutrients. 10(10).
Abstract
(1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping