PUBLICATION
Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio)
- Authors
- Jia, J., Zhang, Y., Yuan, X., Qin, J., Yang, G., Yu, X., Wang, B., Sun, C., Li, W.
- ID
- ZDB-PUB-180327-4
- Date
- 2018
- Source
- Biochemical and Biophysical Research Communications 499(2): 285-290 (Journal)
- Registered Authors
- Keywords
- Compensatory growth, Liver, Reactive oxygen species, Zebrafish, mTOR, nrf2
- MeSH Terms
-
- Animals
- Cyclic N-Oxides/pharmacology
- Feeding Behavior/drug effects
- Female
- Intestines/drug effects
- Intestines/metabolism
- Liver/drug effects
- Liver/physiology*
- Mitochondria, Liver/drug effects
- Mitochondria, Liver/metabolism
- Muscle Fibers, Skeletal/drug effects
- Muscle Fibers, Skeletal/metabolism
- Oxidative Phosphorylation/drug effects
- Reactive Oxygen Species/metabolism*
- Signal Transduction/drug effects
- Spin Labels
- Zebrafish/growth & development*
- Zebrafish/metabolism*
- PubMed
- 29574160 Full text @ Biochem. Biophys. Res. Commun.
Citation
Jia, J., Zhang, Y., Yuan, X., Qin, J., Yang, G., Yu, X., Wang, B., Sun, C., Li, W. (2018) Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio). Biochemical and Biophysical Research Communications. 499(2):285-290.
Abstract
Compensatory growth (CG) is defined as a phase of accelerated growth when the disadvantageous environment is improved, accompanied by metabolic adjustment. Here, we report that hepatic oxidative phosphorylation (OXPHOS) activity was enhanced during compensatory growth in zebrafish. Mitochondrial metabolism enabled the generation of reactive oxygen species (ROS), which activated the nrf2 (nuclear factor-erythroid 2-related factor 2) signaling pathway, as well as the mTOR signaling pathway. Tempol (a superoxide dismutase mimetic) treatment blocked ROS signaling in the liver as well as CG in zebrafish. These results demonstrated that mitochondrial ROS signaling are essential for the occurrence of compensatory growth in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping