PUBLICATION
Neuronal expression patterns of the PlexinA family during zebrafish development
- Authors
- Emerson, S.E., Light, S.E., Ebert, A.M.
- ID
- ZDB-PUB-171107-2
- Date
- 2017
- Source
- Gene expression patterns : GEP 27: 56-66 (Journal)
- Registered Authors
- Keywords
- Eye development, In situ hybridization, Retina, Semaphorin, plexinA1a, plexinA1b
- MeSH Terms
-
- Animals
- Cell Adhesion Molecules/genetics
- Cell Adhesion Molecules/metabolism*
- Cells, Cultured
- Gene Expression Regulation, Developmental*
- PubMed
- 29107805 Full text @ Gene Expr. Patterns
Abstract
Plexins (Plxns) and Semaphorins (Semas) are key signaling molecules that regulate many aspects of development. Plxns are a family of transmembrane protein receptors that are activated upon extracellular binding by Semas. Activated Plxns trigger intracellular signaling cascades, which regulate a range of developmental processes, including axon guidance, neuronal positioning and vasculogenesis. Semas are a large family of both transmembrane and secreted signaling molecules, and show subtype specific binding to different Plxn family members. Each Plxn can play different roles in development, and so tightly regulated temporal and spatial expression of receptor subtypes is critical to ensure appropriate signaling. Here we elucidate the expression profiles of the plxnA family, plxnA1a, A1b, A2, A3 and A4 at 18, 24, 36, 48, 60 and 72 h post fertilization in the developing zebrafish. We show that PlxnA family members are expressed in neuronal tissues during zebrafish development, but exhibit key differences in expression within these tissues. We also highlight that plxnA1 has two genes in zebrafish, A1a and A1b, which show divergences in expression patterns during early development.
Genes / Markers
Figure Gallery (6 images)
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping